Buspirone HCl | MJ-90221 | CAS#33386-08-2 | Anxiolytic Psychotropic

MedKoo Cat#: 317360 | Name: Buspirone HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Buspirone is an anxiolytic psychotropic drug of the azapirone chemical class. It is primarily used to treat generalized anxiety disorder (GAD). Unlike most drugs predominantly used to treat anxiety, buspirone's pharmacology is not related to benzodiazepines or barbiturates, and so does not carry the risk of physical dependence and withdrawal symptoms for which those drug classes are known.

Chemical Structure

Buspirone HCl

CAS#33386-08-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 317360

Name: Buspirone HCl

CAS#: 33386-08-2 (HCl)

Chemical Formula: C21H32ClN5O2

Exact Mass: 0.0000

Molecular Weight: 421.97

Elemental Analysis: C, 59.77; H, 7.64; Cl, 8.40; N, 16.60; O, 7.58

Price and Availability

Size	Price	Availability	Quantity
1g	USD 350.00	2 Weeks
5g	USD 850.00	2 Weeks

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Related CAS #

36505-84-7 (free base) 33386-08-2 (HCl)

Synonym

Buspirone HCl; Buspirone hydrochloride; Buspirone, Buspar, MJ 9022 1, MJ-9022-1, MJ90221, MJ9022 1, MJ9022-1; 5-HT1A serotonin receptor agonist

IUPAC/Chemical Name

8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride

InChi Key

RICLFGYGYQXUFH-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

SMILES Code

O=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4.Cl

Appearance

White crystalline powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Buspirone hydrochloride is an anxiolytic psychotropic drug, is used to treat generalized anxiety disorder (GAD).

In vitro activity:

Buspirone counteracted LPS-induced NO release, NOS2, IL-1β and TNF-α gene expression in WT cells, whereas it exerted limited effects in Drd3-/- or Htr1a-/- microglia. In summary, findings indicate that buspirone attenuates microglial polarization after LPS challenge. Reference: Cells. 2021 May 25;10(6):1312. https://pubmed.ncbi.nlm.nih.gov/34070429/

In vivo activity:

Exposure to IS increased the anxiety-/depression-like behaviors: it decreased the time spent in the open arm (OT) in the elevated plus maze (EPM) task and time spent in the light box (TL) in the light/dark transition (LDT) task and increased immobility times in the tail suspension test (TST) and forced swimming test (FST) (Fig. 1A–D). However, oral administration of buspirone significantly reduced IS-induced anxiety-/depression-like behaviors and suppressed IL-1β and TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus (Fig. 1A–G, Supplementary Fig. S1A). Reference: Sci Rep. 2021; 11: 6094. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969772/

	Solvent	mg/mL	mM
Solubility
	DMSO	46.6	110.32
	DMF	10.0	23.70
	Ethanol	23.0	54.51
	PBS (pH 7.2)	10.0	23.70
	Water	75.4	178.69

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 421.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Thomas Broome S, Fisher T, Faiz A, Keay KA, Musumeci G, Al-Badri G, Castorina A. Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells. Cells. 2021 May 25;10(6):1312. doi: 10.3390/cells10061312. PMID: 34070429; PMCID: PMC8229595. 2. Kim JK, Han SK, Joo MK, Kim DH. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094. doi: 10.1038/s41598-021-85681-w. PMID: 33731795; PMCID: PMC7969772. 3. Develle Y, Leblond H. Biphasic Effect of Buspirone on the H-Reflex in Acute Spinal Decerebrated Mice. Front Cell Neurosci. 2020 Jan 15;13:573. doi: 10.3389/fncel.2019.00573. PMID: 32009904; PMCID: PMC6974439.

In vitro protocol:

In vivo protocol:

1. Kim JK, Han SK, Joo MK, Kim DH. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094. doi: 10.1038/s41598-021-85681-w. PMID: 33731795; PMCID: PMC7969772. 2. Develle Y, Leblond H. Biphasic Effect of Buspirone on the H-Reflex in Acute Spinal Decerebrated Mice. Front Cell Neurosci. 2020 Jan 15;13:573. doi: 10.3389/fncel.2019.00573. PMID: 32009904; PMCID: PMC6974439.

1: Howland RH. Buspirone: Back to the Future. J Psychosoc Nurs Ment Health Serv. 2015 Nov 1;53(11):21-4. doi: 10.3928/02793695-20151022-01. PubMed PMID: 26535760. 2: Kingsberg SA, Clayton AH, Pfaus JG. The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder. CNS Drugs. 2015 Oct 30. [Epub ahead of print] PubMed PMID: 26519340. 3: Kuchiiwa T, Kuchiiwa S. Evaluation of aggressiveness of female mice using a semi-automated apparatus for measurement of aggressive biting behavior toward an inanimate object. J Neurosci Methods. 2015 Oct 17;257:179-184. doi: 10.1016/j.jneumeth.2015.10.005. [Epub ahead of print] PubMed PMID: 26484786.