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MedKoo Cat#: 527931 | Name: Buspirone free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Buspirone is an anxiolytic psychotropic drug of the azapirone chemical class. It is primarily used to treat generalized anxiety disorder (GAD). Unlike most drugs predominantly used to treat anxiety, buspirone's pharmacology is not related to benzodiazepines or barbiturates, and so does not carry the risk of physical dependence and withdrawal symptoms for which those drug classes are known.

Chemical Structure

Buspirone free base
Buspirone free base
CAS#36505-84-7 (free base)

Theoretical Analysis

MedKoo Cat#: 527931

Name: Buspirone free base

CAS#: 36505-84-7 (free base)

Chemical Formula: C21H31N5O2

Exact Mass: 385.2478

Molecular Weight: 385.51

Elemental Analysis: C, 65.43; H, 8.11; N, 18.17; O, 8.30

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
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Related CAS #
36505-84-7 (free base) 33386-08-2 (HCl)
Synonym
Buspirone free base, Buspirone, Buspar, MJ 9022 1, MJ-9022-1, MJ90221, MJ9022 1, MJ9022-1
IUPAC/Chemical Name
8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione
InChi Key
QWCRAEMEVRGPNT-UHFFFAOYSA-N
InChi Code
1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
SMILES Code
c1cnc(nc1)N2CCN(CC2)CCCCN3C(=O)CC4(CCCC4)CC3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Torrisi SA, Salomone S, Geraci F, Caraci F, Bucolo C, Drago F, Leggio GM. Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade. Front Pharmacol. 2017 Oct 4;8:710. doi: 10.3389/fphar.2017.00710. eCollection 2017. PubMed PMID: 29046641; PubMed Central PMCID: PMC5632784. 2: Reynolds AR, Strickland JC, Stoops WW, Lile JA, Rush CR. Buspirone maintenance does not alter the reinforcing, subjective, and cardiovascular effects of intranasal methamphetamine. Drug Alcohol Depend. 2017 Dec 1;181:25-29. doi: 10.1016/j.drugalcdep.2017.08.038. Epub 2017 Sep 22. PubMed PMID: 29028556; PubMed Central PMCID: PMC5683915. 3: Di Ciano P, Cormick PM, Stefan C, Wong E, Kim A, Remington G, Le Foll B. The effects of buspirone on occupancy of dopamine receptors and the rat gambling task. Psychopharmacology (Berl). 2017 Nov;234(22):3309-3320. doi: 10.1007/s00213-017-4715-5. Epub 2017 Aug 19. PubMed PMID: 28825117. 4: Santa Cruz MR, Hidalgo PC, Lee MS, Thomas CW, Holroyd S. Buspirone for the treatment of dementia with behavioral disturbance. Int Psychogeriatr. 2017 May;29(5):859-862. doi: 10.1017/S1041610216002441. Epub 2017 Jan 26. PubMed PMID: 28124634. 5: D'Amico JM, Butler AA, Héroux ME, Cotel F, Perrier JM, Butler JE, Gandevia SC, Taylor JL. Human motoneurone excitability is depressed by activation of serotonin 1A receptors with buspirone. J Physiol. 2017 Mar 1;595(5):1763-1773. doi: 10.1113/JP273200. Epub 2016 Dec 17. PubMed PMID: 27859267; PubMed Central PMCID: PMC5330870. 6: Chugani DC, Chugani HT, Wiznitzer M, Parikh S, Evans PA, Hansen RL, Nass R, Janisse JJ, Dixon-Thomas P, Behen M, Rothermel R, Parker JS, Kumar A, Muzik O, Edwards DJ, Hirtz D; Autism Center of Excellence Network. Efficacy of Low-Dose Buspirone for Restricted and Repetitive Behavior in Young Children with Autism Spectrum Disorder: A Randomized Trial. J Pediatr. 2016 Mar;170:45-53.e1-4. doi: 10.1016/j.jpeds.2015.11.033. Epub 2015 Dec 30. PubMed PMID: 26746121. 7: Howland RH. Buspirone: Back to the Future. J Psychosoc Nurs Ment Health Serv. 2015 Nov;53(11):21-4. doi: 10.3928/02793695-20151022-01. Review. PubMed PMID: 26535760. 8: McRae-Clark AL, Baker NL, Gray KM, Killeen TK, Wagner AM, Brady KT, DeVane CL, Norton J. Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial. Drug Alcohol Depend. 2015 Nov 1;156:29-37. doi: 10.1016/j.drugalcdep.2015.08.013. Epub 2015 Aug 25. PubMed PMID: 26386827; PubMed Central PMCID: PMC4633378. 9: Le Foll B, Payer D, Di Ciano P, Guranda M, Nakajima S, Tong J, Mansouri E, Wilson AA, Houle S, Meyer JH, Graff-Guerrero A, Boileau I. Occupancy of Dopamine D3 and D2 Receptors by Buspirone: A [11C]-(+)-PHNO PET Study in Humans. Neuropsychopharmacology. 2016 Jan;41(2):529-37. doi: 10.1038/npp.2015.177. Epub 2015 Jun 19. PubMed PMID: 26089182; PubMed Central PMCID: PMC5130128.

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