GSK-5959 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). GSK-5959 exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1 (bromodomain and PHD finger containing protein 1) is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
MedKoo Cat#: 407157
Name: GSK-5959
CAS#: 901245-65-6
Chemical Formula: C22H26N4O3
Exact Mass: 394.2005
Molecular Weight: 394.48
Elemental Analysis: C, 66.99; H, 6.64; N, 14.20; O, 12.17
The following data is based on the product molecular weight 394.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
