TCMDC-125457 | CAS#unknown | Malaria calcium dynamics disruptor

MedKoo Cat#: 465990 | Name: TCMDC-125457

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCMDC-125457 is a novel disruptor of the malaria parasite calcium dynamics, potently inducing calcium redistribution but minimally inhibiting heme crystallization.

Chemical Structure

TCMDC-125457

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465990

Name: TCMDC-125457

CAS#: unknown

Chemical Formula: C19H18ClN5O3

Exact Mass: 399.1098

Molecular Weight: 399.84

Elemental Analysis: C, 57.08; H, 4.54; Cl, 8.87; N, 17.52; O, 12.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TCMDC-125457; TCMDC125457; TCMDC 125457;

IUPAC/Chemical Name

N-(2-((5-chloro-2-methoxyphenyl)amino)-2-oxoethyl)-N-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide

InChi Key

RHRZUZMCICRKJA-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H18ClN5O3/c1-24(12-18(26)22-15-10-13(20)8-9-17(15)28-2)19(27)16-11-21-25(23-16)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3,(H,22,26)

SMILES Code

O=C(C1=NN(C2=CC=CC=C2)N=C1)N(CC(NC3=CC(Cl)=CC=C3OC)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 399.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chia W, Gomez-Lorenzo MG, Castellote I, Tong JX, Chandramohanadas R, Thu Chu TT, Shen W, Go ML, de Cozar C, Crespo B, Almela MJ, Neria-Serrano F, Franco V, Gamo FJ, Tan KSW. High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics. ACS Chem Biol. 2021 Nov 19;16(11):2348-2372. doi: 10.1021/acschembio.1c00512. Epub 2021 Oct 5. PMID: 34609851.