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MedKoo Cat#: 561659 | Name: Propentofylline
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propentofylline is a phosphodiesterase inhibitor with neuroprotective effect. It was studied for the treatment of Alzheimer's disease and multi-infarct dementia, as well as its action as an adenosine reuptake inhibitor. Propentofylline is a treatment of feline infectious peritonitis.

Chemical Structure

Propentofylline
Propentofylline
CAS#55242-55-2

Theoretical Analysis

MedKoo Cat#: 561659

Name: Propentofylline

CAS#: 55242-55-2

Chemical Formula: C15H22N4O3

Exact Mass: 306.1692

Molecular Weight: 306.36

Elemental Analysis: C, 58.81; H, 7.24; N, 18.29; O, 15.67

Price and Availability

Size Price Availability Quantity
10mg USD 400.00 2 Weeks
25mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
Propentofylline; Hextol; Karsivan; Propentophylline; HWA-285; HWA 285; HWA285;
IUPAC/Chemical Name
3-Methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione
InChi Key
RBQOQRRFDPXAGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3
SMILES Code
O=C(N1CCCCC(C)=O)N(C)C2=C(N(CCC)C=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 306.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shamabadi A, Karimi H, Arabzadeh Bahri R, Motavaselian M, Akhondzadeh S. Emerging drugs for the treatment of irritability associated with autism spectrum disorder. Expert Opin Emerg Drugs. 2024 Mar;29(1):45-56. doi: 10.1080/14728214.2024.2313650. Epub 2024 Feb 4. PMID: 38296815. 2: Krentz D, Bergmann M, Felten S, Hartmann K. Optionen zur Therapie der felinen infektiösen Peritonitis – früher und heute [Options for treatment of feline infectious peritonitis - previously and today]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2023 Oct;51(5):351-360.. German. doi: 10.1055/a-2147-3999. Epub 2023 Nov 13. PMID: 37956666. 3: Capuzzi E, Caldiroli A, Quitadamo C, Butturini F, Surace T, Clerici M, Buoli M. Novel pharmacotherapy targeting the positive symptoms of schizophrenia. Expert Opin Pharmacother. 2023 Sep-Dec;24(14):1623-1648. doi: 10.1080/14656566.2023.2231346. Epub 2023 Jul 10. PMID: 37401388. 4: Baliellas DEM, Barros MP, Vardaris CV, Guariroba M, Poppe SC, Martins MF, Pereira ÁAF, Bondan EF. Propentofylline Improves Thiol-Based Antioxidant Defenses and Limits Lipid Peroxidation following Gliotoxic Injury in the Rat Brainstem. Biomedicines. 2023 Jun 7;11(6):1652. doi: 10.3390/biomedicines11061652. PMID: 37371747; PMCID: PMC10296019. 5: Janitschke D, Lauer AA, Bachmann CM, Winkler J, Griebsch LV, Pilz SM, Theiss EL, Grimm HS, Hartmann T, Grimm MOW. Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. Int J Mol Sci. 2022 Feb 18;23(4):2295. doi: 10.3390/ijms23042295. PMID: 35216410; PMCID: PMC8875332. 6: Sordo L, Gunn-Moore DA. Cognitive Dysfunction in Cats: Update on Neuropathological and Behavioural Changes Plus Clinical Management. Vet Rec. 2021 Jan;188(1):e3. doi: 10.1002/vetr.3. Epub 2021 Jan 12. PMID: 34651755. 7: Janitschke D, Lauer AA, Bachmann CM, Grimm HS, Hartmann T, Grimm MOW. Methylxanthines and Neurodegenerative Diseases: An Update. Nutrients. 2021 Feb 28;13(3):803. doi: 10.3390/nu13030803. PMID: 33671099; PMCID: PMC8000915. 8: Janitschke D, Lauer AA, Bachmann CM, Seyfried M, Grimm HS, Hartmann T, Grimm MOW. Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells. Int J Mol Sci. 2020 Nov 27;21(23):9015. doi: 10.3390/ijms21239015. PMID: 33260941; PMCID: PMC7730563. 9: Choi GJ, Kang H, Lee JM, Baek CW, Jung YH, Woo YC, Do JH, Ko JS. Effect of intraperitoneally administered propentofylline in a rat model of postoperative pain. Korean J Pain. 2020 Oct 1;33(4):326-334. doi: 10.3344/kjp.2020.33.4.326. PMID: 32989197; PMCID: PMC7532297. 10: Radulescu SM, Humm K, Eramanis LM, Volk HA, Church DB, Brodbelt D, O'Neill DG. Vestibular disease in dogs under UK primary veterinary care: Epidemiology and clinical management. J Vet Intern Med. 2020 Sep;34(5):1993-2004. doi: 10.1111/jvim.15869. Epub 2020 Aug 10. PMID: 32776616; PMCID: PMC7517853. 11: Sanders O, Rajagopal L. Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale. J Alzheimers Dis Rep. 2020 Jun 16;4(1):185-215. doi: 10.3233/ADR-200191. PMID: 32715279; PMCID: PMC7369141. 12: Araya EI, Turnes JM, Barroso AR, Chichorro JG. Contribution of intraganglionic CGRP to migraine-like responses in male and female rats. Cephalalgia. 2020 Jun;40(7):689-700. doi: 10.1177/0333102419896539. Epub 2019 Dec 19. PMID: 31856582. 13: Behmanesh H, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Risperidone Combination Therapy With Propentofylline for Treatment of Irritability in Autism Spectrum Disorders: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Clin Neuropharmacol. 2019 Nov/Dec;42(6):189-196. doi: 10.1097/WNF.0000000000000368. PMID: 31725473. 14: Janitschke D, Nelke C, Lauer AA, Regner L, Winkler J, Thiel A, Grimm HS, Hartmann T, Grimm MOW. Effect of Caffeine and Other Methylxanthines on Aβ- Homeostasis in SH-SY5Y Cells. Biomolecules. 2019 Nov 2;9(11):689. doi: 10.3390/biom9110689. PMID: 31684105; PMCID: PMC6920871. 15: Yang Y, Shi Y, Jia J, Wang S, Chang H, Li M, Jin X, Wang J. Propentofylline reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatase-1: An experimental study in a rat model of acute incisional pain. Neurol Res. 2019 Oct;41(10):900-908. doi: 10.1080/01616412.2019.1642437. Epub 2019 Aug 12. PMID: 31402773. 16: Rezaee L, Manaheji H, Haghparast A. Role of spinal glial cells in excitability of wide dynamic range neurons and the development of neuropathic pain with the L5 spinal nerve transection in the rats: Behavioral and electrophysiological study. Physiol Behav. 2019 Oct 1;209:112597. doi: 10.1016/j.physbeh.2019.112597. Epub 2019 Jul 2. PMID: 31271834. 17: Santa-Cecília FV, Ferreira DW, Guimaraes RM, Cecilio NT, Fonseca MM, Lopes AH, Davoli-Ferreira M, Kusuda R, Souza GR, Nachbur U, Alves-Filho JC, Teixeira MM, Zamboni DS, Cunha FQ, Cunha TM. The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development. Pain. 2019 Jan;160(1):102-116. doi: 10.1097/j.pain.0000000000001383. PMID: 30169421. 18: Fujita M, Tamano R, Yoneda S, Omachi S, Yogo E, Rokushima M, Shinohara S, Sakaguchi G, Hasegawa M, Asaki T. Ibudilast produces anti-allodynic effects at the persistent phase of peripheral or central neuropathic pain in rats: Different inhibitory mechanism on spinal microglia from minocycline and propentofylline. Eur J Pharmacol. 2018 Aug 15;833:263-274. doi: 10.1016/j.ejphar.2018.06.009. Epub 2018 Jun 7. PMID: 29886243. 19: Bondan EF, Vieira CC, Martins MFM, Kirsten TB, Bernardi MM. Propentofylline decreases hypothalamic astrogliosis induced by hypercaloric diet in the rat. Arq Neuropsiquiatr. 2018 Apr;76(4):252-256. doi: 10.1590/0004-282x20180019. PMID: 29742238. 20: Cisneros IE, Erdenizmenli M, Cunningham KA, Paessler S, Dineley KT. Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes. Neuropharmacology. 2018 Jun;135:431-443. doi: 10.1016/j.neuropharm.2018.03.019. Epub 2018 Mar 23. PMID: 29578037; PMCID: PMC5975185.