Synonym
Broxaldine; AL 307; AL-307; AL307
IUPAC/Chemical Name
5,7-Dibromo-2-methyl-8-quinolinol benzoate ester
InChi Key
IJTPLVAAROHGGB-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H11Br2NO2/c1-10-7-8-12-13(18)9-14(19)16(15(12)20-10)22-17(21)11-5-3-2-4-6-11/h2-9H,1H3
SMILES Code
CC1=NC2=C(OC(C3=CC=CC=C3)=O)C(Br)=CC(Br)=C2C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
421.09
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ghajar-Rahimi G, Traylor AM, Mathew B, Bostwick JR, Nebane NM, Zmijewska AA, Esman SK, Thukral S, Zhai L, Sambandam V, Cowell RM, Suto MJ, George JF, Augelli-Szafran CE, Agarwal A. Identification of Cytoprotective Small-Molecule Inducers of Heme-Oxygenase-1. Antioxidants (Basel). 2022 Sep 23;11(10):1888. doi: 10.3390/antiox11101888. PMID: 36290611; PMCID: PMC9598442.
2: Sharma CS. Letter: Effect of broxyquinoline and broxaldine in leprosy. Lancet. 1975 Feb 15;1(7903):405. doi: 10.1016/s0140-6736(75)91334-3. PMID: 46561.
3: Pashov D, Simeonov SP, Drumev D, Peĭnikova Ts, Dzhurov A. Prouchvaniia vŭrkhu toksichnostta na niakoi khidroksikhinolinovi proizvodni [Toxicity of hydroxyquinoline derivatives]. Vet Med Nauki. 1980;17(3):118-23. Bulgarian. PMID: 6784325.
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