MedKoo Cat#: 407151 | Name: A77-01
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 77-01 is an inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25nM.

Chemical Structure

A77-01
A77-01
CAS#607737-87-1

Theoretical Analysis

MedKoo Cat#: 407151

Name: A77-01

CAS#: 607737-87-1

Chemical Formula: C18H14N4

Exact Mass: 286.1219

Molecular Weight: 286.33

Elemental Analysis: C, 75.50; H, 4.93; N, 19.57

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
25mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
A77-01; A 77-01; A-77-01.
IUPAC/Chemical Name
4-(5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline
InChi Key
KJTYZDORHCDZPS-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22)
SMILES Code
CC1=CC=CC(=N1)C2=C(C=NN2)C3=CC=NC4=CC=CC=C34
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 286.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dick RA. Refinement of In Vitro Methods for Identification of Aldehyde Oxidase Substrates Reveals Metabolites of Kinase Inhibitors. Drug Metab Dispos. 2018 Jun;46(6):846-859. doi: 10.1124/dmd.118.080960. Epub 2018 Apr 3. PMID: 29615437.