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MedKoo Cat#: 561590 | Name: (R)-Oxiracetam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-Oxiracetam is a nootropic drug. It has been shown to improve cognition and memory.

Chemical Structure

(R)-Oxiracetam
(R)-Oxiracetam
CAS#68252-28-8

Theoretical Analysis

MedKoo Cat#: 561590

Name: (R)-Oxiracetam

CAS#: 68252-28-8

Chemical Formula: C6H10N2O3

Exact Mass: 158.0691

Molecular Weight: 158.15

Elemental Analysis: C, 45.57; H, 6.37; N, 17.71; O, 30.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
(R)-Oxiracetam; R-Oxiracetam; (R)-ISF-2522;
IUPAC/Chemical Name
2-[(4R)-4-Hydroxy-2-oxopyrrolidin-1-yl]acetamide
InChi Key
IHLAQQPQKRMGSS-SCSAIBSYSA-N
InChi Code
InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)/t4-/m1/s1
SMILES Code
O=C(N)CN1C(C[C@@H](O)C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 158.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li W, Liu H, Jiang H, Wang C, Guo Y, Sun Y, Zhao X, Xiong X, Zhang X, Zhang K, Nie Z, Pu X. (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats. Sci Rep. 2017 Aug 30;7(1):10052. doi: 10.1038/s41598-017-10283-4. PubMed PMID: 28855592; PubMed Central PMCID: PMC5577264. 2: Wang W, Ji H, Li T, Jia Y, Xie H. Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs. Acta Pharm. 2016 Jun 1;66(2):279-87. doi: 10.1515/acph-2016-0013. PubMed PMID: 27279070. 3: Zhang Q, Yang W, Zhang Q, Yang Y, Li J, Lu Y, Zheng Y, He J, Zhao D, Chen X. Enantioselective HPLC determination of oxiracetam enantiomers and application to a pharmacokinetic study in beagle dogs. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 1;993-994:9-13. doi: 10.1016/j.jchromb.2015.04.033. Epub 2015 Apr 30. PubMed PMID: 25978861. 4: Chen J, Zhou SN, Zhang YM, Feng YL, Wang S. Glycosides of cistanche improve learning and memory in the rat model of vascular dementia. Eur Rev Med Pharmacol Sci. 2015 Apr;19(7):1234-40. PubMed PMID: 25912583. 5: Zhang Q, Yang W, Yang Y, Xing H, Zhang Q, Li J, Lu Y, He J, Yang S, Zhao D, Chen X. Comparative pharmacokinetic studies of racemic oxiracetam and its pure enantiomers after oral administration in rats by a stereoselective HPLC method. J Pharm Biomed Anal. 2015;111:153-8. doi: 10.1016/j.jpba.2015.03.039. Epub 2015 Apr 4. PubMed PMID: 25886392. 6: Wan X, Wang H, Ma P, Xi L, Sun J, He Z, Zhang X, Liu X. Simultaneous determination of oxiracetam and its degraded substance in rat plasma by HPLC-MS/MS and its application to pharmacokinetic study after a single high-dose intravenous administration. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:95-100. doi: 10.1016/j.jchromb.2014.07.041. Epub 2014 Aug 4. PubMed PMID: 25168792. 7: Pace V, Rae JP, Procter DJ. Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides. Org Lett. 2014 Jan 17;16(2):476-9. doi: 10.1021/ol4033623. Epub 2013 Dec 18. PubMed PMID: 24350760. 8: Son J, Lee J, Lee M, Lee E, Lee JH, La S, Kim DH. Rapid quantitative analysis of oxiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry. J Pharm Biomed Anal. 2004 Nov 15;36(3):657-61. PubMed PMID: 15522546. 9: Son J, Lee J, Lee M, Lee E, Lee KT, La S, Kim DH. Rapid quantitative analysis of oxiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry. J Pharm Biomed Anal. 2004 Sep 21;36(1):183-7. PubMed PMID: 15351064. 10: Dudkin SM, Polev PV, Soldatov NM. Calcium entry blockers and oxiracetam have opposite effects on the density of dihydropyridine receptors in rat cerebral cortex. Brain Res. 1990 Aug 20;525(2):319-21. PubMed PMID: 2174714. 11: Verloes R, Scotto AM, Gobert J, Wülfert E. Effects of nootropic drugs in a scopolamine-induced amnesia model in mice. Psychopharmacology (Berl). 1988;95(2):226-30. PubMed PMID: 3137602.

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