TMP778 is a novel, potent, and selective RORıt inverse agonist. TMP778 acts potently and selectively to block mouse Th17 cell differentiation in vitro and to impair Th17 cell development in vivo upon immunization with the myelin antigen MOG35-55 plus complete Freund's adjuvant. Importantly, TMP778 acts in vivo to repress the expression of more than 150 genes, most of which fall outside the canonical Th17 transcriptional signature and are linked to a variety of inflammatory pathologies in humans.
MedKoo Cat#: 522368
Name: TMP778
CAS#: 1422053-04-0
Chemical Formula: C31H30N2O4
Exact Mass: 494.2206
Molecular Weight: 494.59
Elemental Analysis: C, 75.28; H, 6.11; N, 5.66; O, 12.94
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 200.0 | 404.00 |
The following data is based on the product molecular weight 494.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
