HPI-1 is a Hedgehog (Hh) signaling inhibitor that inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells. HPI-1 also inhibits Hh pathway activation in SmoM2-LIGHT cells and the proliferation of cerebellar granule neuron precursors expressing SmoM2. HPI-1 does not inhibit Wnt signaling.
MedKoo Cat#: 574733
Name: HPI-1
CAS#: 599150-20-6
Chemical Formula: C27H29NO6
Exact Mass: 463.1995
Molecular Weight: 463.53
Elemental Analysis: C, 69.96; H, 6.31; N, 3.02; O, 20.71
The following data is based on the product molecular weight 463.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
