Synonym
ICI 111581; ICI-111581; ICI111581; ICI118551; ICI 118551; ICI-118551; ICI118,551; ICI 118,551; ICI-118,551; ICI-118551 HCl.
IUPAC/Chemical Name
(2R,3R)-3-(isopropylamino)-1-((7-methyl-2,3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride
InChi Key
KBXMBGWSOLBOQM-CACIRBSMSA-N
InChi Code
InChI=1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16+;/m1./s1
SMILES Code
C[C@@H](NC(C)C)[C@@H](O)COC1=CC=C(C)C2=C1CCC2.[H]Cl
Appearance
white to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
313.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Moresco RM, Matarrese M, Soloviev D, Simonelli P, Rigamonti M, Gobbo C, Todde S, Carpinelli A, Kienle MG, Fazio F. Synthesis and in vivo evaluation of [11C]ICI 118551 as a putative subtype selective beta2-adrenergic radioligand. Int J Pharm. 2000 Aug 25;204(1-2):101-9. PubMed PMID: 11011992.
2: Hopkinson HE, Latif ML, Hill SJ. Non-competitive antagonism of beta(2)-agonist-mediated cyclic AMP accumulation by ICI 118551 in BC3H1 cells endogenously expressing constitutively active beta(2)-adrenoceptors. Br J Pharmacol. 2000 Sep;131(1):124-30. PubMed PMID: 10960078; PubMed Central PMCID: PMC1572294.
3: Quaglia MG, Farina A, Bossu E. Analysis of ICI 118551, a new beta 2 blocking drug, and related compounds by RP-HPLC-DAD. J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):1081-4. PubMed PMID: 1363686.
4: Jefferson D, Wharrad HJ, Birmingham AT, Patrick JM. The comparative effects of ICI 118551 and propranolol on essential tremor. Br J Clin Pharmacol. 1987 Dec;24(6):729-34. PubMed PMID: 2894217; PubMed Central PMCID: PMC1386396.
5: King DJ, Devaney NM, Gilbert JK. A double-blind placebo controlled trial of a selective beta 2 adrenoceptor antagonist (ICI 118551) in chronic anxiety. Int Clin Psychopharmacol. 1987 Jul;2(3):191-200. PubMed PMID: 3320184.
6: Tattersfield AE, Cragg DJ. Effect of ICI 118551 on bronchial beta-adrenoceptor function and exercise heart rate in normal man. Br J Clin Pharmacol. 1983 Dec;16(6):587-90. PubMed PMID: 6140938; PubMed Central PMCID: PMC1428330.
