AEG-40826 | CAS#949963-04-6 | IAP Inhibitor

MedKoo Cat#: 201475 | Name: AEG40826

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.

Chemical Structure

AEG40826

CAS#949963-04-6

Theoretical Analysis

MedKoo Cat#: 201475

Name: AEG40826

CAS#: 949963-04-6

Chemical Formula: C58H80N10O8

Exact Mass: 1044.6161

Molecular Weight: 1045.34

Elemental Analysis: C, 66.64; H, 7.71; N, 13.40; O, 12.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

HGS1029; HGS-1029; HGS 1029; AEG40826; AEG-40826; AEG 40826; AEG408262 HCl.

IUPAC/Chemical Name

N1,N4-bis((3S,5S)-1-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)terephthalamide

InChi Key

ZPZYSWMWQKSQBU-HFMNLVBRSA-N

InChi Code

InChI=1S/C58H80N10O8/c1-33(59-9)49(69)65-47(57(3,4)5)55(75)67-31-39(29-45(67)53(73)63-43-23-15-19-35-17-11-13-21-41(35)43)61-51(71)37-25-27-38(28-26-37)52(72)62-40-30-46(54(74)64-44-24-16-20-36-18-12-14-22-42(36)44)68(32-40)56(76)48(58(6,7)8)66-50(70)34(2)60-10/h11-14,17-18,21-22,25-28,33-34,39-40,43-48,59-60H,15-16,19-20,23-24,29-32H2,1-10H3,(H,61,71)(H,62,72)(H,63,73)(H,64,74)(H,65,69)(H,66,70)/t33-,34-,39-,40-,43+,44+,45-,46-,47+,48+/m0/s1

SMILES Code

C[C@H](NC)C(N[C@H](C(N1C[C@@H](NC(C2=CC=C(C(N[C@@H](C[C@H]3C(N[C@@H]4CCCC5=C4C=CC=C5)=O)CN3C([C@H](C(C)(C)C)NC([C@@H](NC)C)=O)=O)=O)C=C2)=O)C[C@H]1C(N[C@@H]6CCCC7=C6C=CC=C7)=O)=O)C(C)(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Aegera has developed extremely potent small molecule IAP inhibitors by targeting functional domains on the individual IAP proteins; These compounds possess good pharmacokinetic/pharmacodynamic properties and stability and demonstrate potent anticancer activity, alone and in combination with current cancer therapies and death receptor agonists. In December 2007, Aegera and Human Genome Sciences, Inc. (Nasdaq:HGSI) completed a licensing and collaboration agreement providing HGS with exclusive worldwide rights (excluding Japan) to develop and commercialize AEG40826 (HGS1029) and other small-molecule IAP inhibitors in oncology. Aegera has retained global rights for the use of its small molecules IAP inhibitors in all indications outside oncology. AEG40826/HGS1029 is currently progressing in Phase 1 studies. (source: http://www.aegera.com/aeg40826.php). (source: http://www.aegera.com/aeg40826.php).

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,045.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.