ZM306416 is a selective antagonist of the vascular endothelial growth factor receptor-2 (VEGFR-2), which plays a crucial role in angiogenesis. It inhibits VEGF-induced receptor activation and downstream signaling, thereby suppressing endothelial cell proliferation, migration, and new blood vessel formation. This mechanism makes it a valuable compound in cancer research, particularly for studying anti-angiogenic therapies aimed at limiting tumor vascularization. Additionally, ZM306416 has potential applications in ophthalmic diseases like age-related macular degeneration, where pathological angiogenesis contributes to disease progression.
MedKoo Cat#: 405580
Name: ZM306416
CAS#: 690206-97-4 (free base)
Chemical Formula: C16H13ClFN3O2
Exact Mass: 333.0680
Molecular Weight: 333.74
Elemental Analysis: C, 57.58; H, 3.93; Cl, 10.62; F, 5.69; N, 12.59; O, 9.59
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.7 | 166.81 | |
| DMF | 50.0 | 149.82 | |
| Ethanol | 20.0 | 59.93 |
The following data is based on the product molecular weight 333.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
