G-6599 is a SMARCA2/A4 (BRM/BRG1) degrader acting via the recruitment of FBXO22. -6599 showed exceptional degradation potency and specificity for SMARCA2/A4. G-6599 operates through the ubiquitin-proteasome pathway and the E3 ligase FBXO22. G-6599 was shown to promote ternary complex formation between SMARCA2 and FBXO22 involving covalent conjugation to a cysteine residue on the latter.
MedKoo Cat#: 128623
Name: G-6599
CAS#: N/A
Chemical Formula: C31H37N7O
Exact Mass: 523.3060
Molecular Weight: 523.69
Elemental Analysis: C, 71.10; H, 7.12; N, 18.72; O, 3.06
The following data is based on the product molecular weight 523.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
