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MedKoo Cat#: 129090 | Name: RGD-DA6

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RGD-DA6 is a Integrin αvβ3-Targeted Radioligand for Enhanced Tumor Accumulation.

Chemical Structure

RGD-DA6
RGD-DA6
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129090

Name: RGD-DA6

CAS#: N/A

Chemical Formula: C78H110IN17O24

Exact Mass: 1795.6954

Molecular Weight: 1796.74

Elemental Analysis: C, 52.14; H, 6.17; I, 7.06; N, 13.25; O, 21.37

Price and Availability

Related CAS #
No Data
Synonym
RGD-DA6; RGDDA6; RGD DA6
IUPAC/Chemical Name
2,2'-(4-(4-((4-((2S,5S,11S,14R)-14-benzyl-11-(carboxymethyl)-5-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)amino)-1-carboxy-4-oxobutyl)-10-(1-carboxy-4-(((R)-4-carboxy-1-(((S)-1-carboxy-5-(4-((4-(4-iodophenyl)butanamido)methyl)benzamido)pentyl)amino)-1-oxobutan-2-yl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid
InChi Key
KUEHWVRXFFAFRW-XADXNFEVSA-N
InChi Code
InChI=1S/C78H110IN17O24/c79-52-23-19-48(20-24-52)12-8-16-61(97)85-44-50-17-21-51(22-18-50)69(109)83-32-7-5-14-56(75(115)116)91-72(112)55(25-30-65(101)102)87-63(99)29-27-60(77(119)120)96-40-36-93(46-67(105)106)34-38-95(39-35-94(37-41-96)47-68(107)108)59(76(117)118)26-28-62(98)82-31-6-4-13-54-71(111)89-53(15-9-33-84-78(80)81)70(110)86-45-64(100)88-58(43-66(103)104)74(114)92-57(73(113)90-54)42-49-10-2-1-3-11-49/h1-3,10-11,17-24,53-60H,4-9,12-16,25-47H2,(H,82,98)(H,83,109)(H,85,97)(H,86,110)(H,87,99)(H,88,100)(H,89,111)(H,90,113)(H,91,112)(H,92,114)(H,101,102)(H,103,104)(H,105,106)(H,107,108)(H,115,116)(H,117,118)(H,119,120)(H4,80,81,84)/t53-,54-,55+,56?,57+,58-,59?,60?/m0/s1
SMILES Code
O=C(N[C@@H](CCCCNC(CCC(C(O)=O)N1CCN(CC(O)=O)CCN(C(C(O)=O)CCC(N[C@H](CCC(O)=O)C(N[C@H](C(O)=O)CCCCNC(C2=CC=C(CNC(CCCC3=CC=C(I)C=C3)=O)C=C2)=O)=O)=O)CCN(CC(O)=O)CC1)=O)C4=O)[C@H](NC([C@H](CC(O)=O)NC(CNC([C@@H](N4)CCCNC(N)=N)=O)=O)=O)CC5=CC=CC=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,796.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

  1. Development of Novel Integrin αvβ3-Targeted Radioligand for Enhanced Tumor Accumulation

    Nobuki Kazuta, Kazuma Nakashima, Hiroyuki Watanabe, and Masahiro Ono
    ACS Medicinal Chemistry Letters Article ASAP
    DOI: 10.1021/acsmedchemlett.5c00231