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MedKoo Cat#: 465904 | Name: PSB-11

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-11 is a A3AR antagonist.

Chemical Structure

PSB-11
PSB-11
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465904

Name: PSB-11

CAS#: unknown

Chemical Formula: C16H17N5O

Exact Mass: 295.1433

Molecular Weight: 295.35

Elemental Analysis: C, 65.07; H, 5.80; N, 23.71; O, 5.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
PSB-11; PSB11; PSB 11;
IUPAC/Chemical Name
(R)-8-ethyl-4-methyl-2-phenyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one
InChi Key
RGDHRCXUMURWBJ-LLVKDONJSA-N
InChi Code
InChI=1S/C16H17N5O/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10/h4-8,11H,3,9H2,1-2H3,(H,18,19)/t11-/m1/s1
SMILES Code
CC[C@H]1N=C2C3=C(N=C(C4=CC=CC=C4)N3)N(C)C(N2C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 295.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bouzo-Lorenzo M, Stoddart LA, Xia L, IJzerman AP, Heitman LH, Briddon SJ, Hill SJ. A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor. Purinergic Signal. 2019 Jun;15(2):139-153. doi: 10.1007/s11302-019-09650-9. Epub 2019 Mar 27. PMID: 30919204; PMCID: PMC6635573. 2: Kim SK, Gao ZG, Jeong LS, Jacobson KA. Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor. J Mol Graph Model. 2006 Dec;25(4):562-77. doi: 10.1016/j.jmgm.2006.05.004. Epub 2006 May 9. PMID: 16793299; PMCID: PMC6262875. 3: Müller CE. Medicinal chemistry of adenosine A3 receptor ligands. Curr Top Med Chem. 2003;3(4):445-62. doi: 10.2174/1568026033392174. PMID: 12570761. 4: Gao ZG, Suresh RR, Jacobson KA. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists. Purinergic Signal. 2021 Dec;17(4):737-746. doi: 10.1007/s11302-021-09823-5. Epub 2021 Oct 28. PMID: 34713378; PMCID: PMC8677861. 5: Xia L, Kyrizaki A, Tosh DK, van Duijl TT, Roorda JC, Jacobson KA, IJzerman AP, Heitman LH. A binding kinetics study of human adenosine A3 receptor agonists. Biochem Pharmacol. 2018 Jul;153:248-259. doi: 10.1016/j.bcp.2017.12.026. Epub 2018 Jan 3. PMID: 29305857; PMCID: PMC5959751. 6: Gao ZG, Kim SK, Gross AS, Chen A, Blaustein JB, Jacobson KA. Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor. Mol Pharmacol. 2003 May;63(5):1021-31. doi: 10.1124/mol.63.5.1021. PMID: 12695530; PMCID: PMC4367541. 7: Gao ZG, Melman N, Erdmann A, Kim SG, Müller CE, IJzerman AP, Jacobson KA. Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors. Biochem Pharmacol. 2003 Feb 15;65(4):525-34. doi: 10.1016/s0006-2952(02)01556-3. PMID: 12566079; PMCID: PMC8607904. 8: Gao ZG, Kim SG, Soltysiak KA, Melman N, IJzerman AP, Jacobson KA. Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives. Mol Pharmacol. 2002 Jul;62(1):81-9. doi: 10.1124/mol.62.1.81. PMID: 12065758; PMCID: PMC3953617. 9: Gao ZG, Jacobson KA. 2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor. Eur J Pharmacol. 2002 May 17;443(1-3):39-42. doi: 10.1016/s0014-2999(02)01552-2. PMID: 12044789; PMCID: PMC8358783. 10: Müller CE, Diekmann M, Thorand M, Ozola V. [(3)H]8-Ethyl-4-methyl-2-phenyl-( 8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors. Bioorg Med Chem Lett. 2002 Feb 11;12(3):501-3. doi: 10.1016/s0960-894x(01)00785-5. PMID: 11814828. 11: Gao ZG, Van Muijlwijk-Koezen JE, Chen A, Müller CE, Ijzerman AP, Jacobson KA. Allosteric modulation of A(3) adenosine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives. Mol Pharmacol. 2001 Nov;60(5):1057-63. PMID: 11641434; PMCID: PMC3953614.