MedKoo Cat#: 206858 | Name: MTX-211
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MTX-211 is a dual inhibitor of EGFR and PI3K. MTX-211 is potentially useful for treatment of KRAS mutant colorectal cancer.

Chemical Structure

MTX-211
MTX-211
CAS#1952236-05-3

Theoretical Analysis

MedKoo Cat#: 206858

Name: MTX-211

CAS#: 1952236-05-3

Chemical Formula: C20H14Cl2FN5O2S

Exact Mass: 477.0229

Molecular Weight: 478.32

Elemental Analysis: C, 50.22; H, 2.95; Cl, 14.82; F, 3.97; N, 14.64; O, 6.69; S, 6.70

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
50mg USD 1,650.00 2 Weeks
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Related CAS #
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Synonym
MTX-211; MTX211; MTX 211
IUPAC/Chemical Name
N-[2-chloro-5-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]pyridin-3-yl]methanesulfonamide
InChi Key
GUYKCXXNIKKSBC-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H14Cl2FN5O2S/c1-31(29,30)28-18-7-12(9-24-19(18)22)11-2-5-17-14(6-11)20(26-10-25-17)27-13-3-4-16(23)15(21)8-13/h2-10,28H,1H3,(H,25,26,27)
SMILES Code
CS(=O)(NC1=CC(C2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2)=CN=C1Cl)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 478.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hu B, Chen R, Jiang M, Xiong S, Xie A, Liu X, Fu B. MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer. Int J Mol Sci. 2023 Apr 20;24(8):7608. doi: 10.3390/ijms24087608. PMID: 37108769; PMCID: PMC10142351. 2: Wu CP, Hung CY, Murakami M, Wu YS, Chu YH, Huang YH, Yu JS, Ambudkar SV. ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor MTX-211 in Cancer Cells. Int J Mol Sci. 2024 May 9;25(10):5160. doi: 10.3390/ijms25105160. PMID: 38791198; PMCID: PMC11121381.