HSD-NTR-B is a NTR-Sensitive Fluorescent H2S Donor as a Potential Therapeutic Agent for Myocardial Ischemia−Reperfusion Injury. HSD-NTR-B significantly improved cardiac structure and function recovery. Mechanistically, its effects stem from inhibiting cardiomyocyte apoptosis and reducing local inflammation. H2S donors modulate macrophage polarization by reducing M1 and increasing M2 macrophages, emerging therapeutic targets for MIRI.
MedKoo Cat#: 129089
Name: HSD-NTR-B
CAS#: N/A
Chemical Formula: C26H24N4O6S
Exact Mass: 520.1417
Molecular Weight: 520.56
Elemental Analysis: C, 59.99; H, 4.65; N, 10.76; O, 18.44; S, 6.16
The following data is based on the product molecular weight 520.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Zhang N, Li T, Zhong P, Fu T, Li L, Peng M, Wang Y, Lu Y, Yao M. Design and Synthesis of a NTR-Sensitive Fluorescent H2S Donor as a Potential Therapeutic Agent for Myocardial Ischemia-Reperfusion Injury. J Med Chem. 2025 Jun 25. doi: 10.1021/acs.jmedchem.5c01169. Epub ahead of print. PMID: 40557820.
