Synonym
GSK 706; GSK-706; GSK706
IUPAC/Chemical Name
2-[((1S)-1-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}ethyl)oxy]-5-[4-(methylsulfonyl)phenyl]pyrazine
InChi Key
BPKMCVFUCFDOST-INIZCTEOSA-N
InChi Code
InChI=1S/C23H29N5O4S/c1-15(2)22-26-23(32-27-22)28-11-9-17(10-12-28)16(3)31-21-14-24-20(13-25-21)18-5-7-19(8-6-18)33(4,29)30/h5-8,13-17H,9-12H2,1-4H3/t16-/m0/s1
SMILES Code
O=S(C1=CC=C(C2=CN=C(O[C@H](C3CCN(C4=NC(C(C)C)=NO4)CC3)C)C=N2)C=C1)(C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
471.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Taylor A, Rothstein D, Rudd CE. Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy. Cancer Res. 2018 Feb 1;78(3):706-717. doi: 10.1158/0008-5472.CAN-17-0491. Epub 2017 Oct 20. PubMed PMID: 29055015.
2: Abberley L. Outsourcing of bioanalysis at GSK: a hybrid approach with a robust support model. Bioanalysis. 2017 Aug;9(15):1139-1144. doi: 10.4155/bio-2017-0062. Epub 2017 Aug 1. PubMed PMID: 28762760.
3: Zafar A, Hasan R, Nizamuddin S, Mahmood N, Mukhtar S, Ali F, Morrissey I, Barker K, Torumkuney D. Antibiotic susceptibility in Streptococcus pneumoniae, Haemophilus influenzae and Streptococcus pyogenes in Pakistan: a review of results from the Survey of Antibiotic Resistance (SOAR) 2002-15. J Antimicrob Chemother. 2016 May;71 Suppl 1:i103-9. doi: 10.1093/jac/dkw076. PubMed PMID: 27048578; PubMed Central PMCID: PMC4890355.
4: Park SJ, Jin ML, An HK, Kim KS, Ko MJ, Kim CM, Choi YW, Lee YC. Emodin induces neurite outgrowth through PI3K/Akt/GSK-3β-mediated signaling pathways in Neuro2a cells. Neurosci Lett. 2015 Feb 19;588:101-7. doi: 10.1016/j.neulet.2015.01.001. Epub 2015 Jan 3. PubMed PMID: 25562207.
5: Noh KT, Cho J, Chun SH, Jang JH, Cha GS, Jung ID, Jang DD, Park YM. Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression. BMB Rep. 2015 May;48(5):283-8. PubMed PMID: 25248565; PubMed Central PMCID: PMC4578568.
6: Hill J, Howatson G, van Someren K, Leeder J, Pedlar C. Compression garments and recovery from exercise-induced muscle damage: a meta-analysis. Br J Sports Med. 2014 Sep;48(18):1340-6. doi: 10.1136/bjsports-2013-092456. Epub 2013 Jun 11. Review. PubMed PMID: 23757486.
7: García-Rey C, Aguilar L, Baquero F, Casal J, Dal-Ré R. Importance of local variations in antibiotic consumption and geographical differences of erythromycin and penicillin resistance in Streptococcus pneumoniae. J Clin Microbiol. 2002 Jan;40(1):159-64. Erratum in: J Clin Microbiol 2002 May;40(5):1885. PubMed PMID: 11773111; PubMed Central PMCID: PMC120130.
