TYM-3-98 is a selective inhibitor for PI3Kδ, with an IC50 of 7.1 nM.
MedKoo Cat#: 129076
Name: TYM-3-98
CAS#: 2820244-59-3
Chemical Formula: C28H23ClFN7O3S
Exact Mass: 591.1256
Molecular Weight: 592.05
Elemental Analysis: C, 56.80; H, 3.92; Cl, 5.99; F, 3.21; N, 16.56; O, 8.11; S, 5.42
The following data is based on the product molecular weight 592.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Lou SY, Zheng FL, Tang YM, Zheng YN, Lu J, An H, Zhang EJ, Cui SL, Zhao HJ.
TYM-3-98, a novel selective inhibitor of PI3Kδ, demonstrates promising
preclinical antitumor activity in B-cell lymphomas. Life Sci. 2024 Jun
15;347:122662. doi: 10.1016/j.lfs.2024.122662. Epub 2024 Apr 24. PMID: 38670450.
2: Zheng YN, Lou SY, Lu J, Zheng FL, Tang YM, Zhang EJ, Cui SL, Zhao HJ.
Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated
lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer. Cell
Death Dis. 2024 Jul 3;15(7):474. doi: 10.1038/s41419-024-06848-7. PMID:
38956060; PMCID: PMC11220027.
3: Zhang E, Lu J, Liu L, Liu L, Hu H, Zheng F, Lou S. Novel PI3Kδ inhibitor
exerts antitumor activity in Burkitt lymphoma by inducing ROS-dependent
apoptosis. Med Oncol. 2025 Jun 21;42(7):277. doi: 10.1007/s12032-025-02837-8.
PMID: 40544227.
