ALN29882| CAS# 24529-88-2 | glycerolipid

MedKoo Cat#: 412692 | Name: ALN29882

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ALN29882 is a glycerolipid, that is located at the plasma membrane. It is made up of two fatty acid chains that are covalently attached to a single glycerol molecule with the help of an ester linkage. 18:1 DG has been used as a diacyl-glycerol source in diacylglycerol O-acyltransferase 1 (DGAT1) assay. It has also been used as substrate to assess compounds as potential inhibitors of DGAT-1 in DGAT-1 enzyme assay. It is suitable to use in lipid-protein overlay screen assay with the recombinant protein His-AtROP6.

Chemical Structure

ALN29882

CAS#24529-88-2

Theoretical Analysis

MedKoo Cat#: 412692

Name: ALN29882

CAS#: 24529-88-2

Chemical Formula: C39H72O5

Exact Mass: 620.5380

Molecular Weight: 621.00

Elemental Analysis: C, 75.43; H, 11.69; O, 12.88

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 Weeks
25mg	USD 650.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

18:1 DG; 1-2-dioleoyl-sn-glycerol; ALN29882; ALN 29882; ALN-29882

IUPAC/Chemical Name

(S)-3-hydroxypropane-1,2-diyl dioleate

InChi Key

AFSHUZFNMVJNKX-LLWMBOQKSA-N

InChi Code

InChI=1S/C39H72O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,37,40H,3-16,21-36H2,1-2H3/b19-17-,20-18-/t37-/m0/s1

SMILES Code

OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

Appearance

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 621.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schmitt JD, Amidon B, Wykle RL, Waite M. Stereospecific labeling of the glycerol moiety: synthesis of 1,2-dioleoyl-sn-[3-3H]glycero-3-phospho(1-rac- glycerol). Chem Phys Lipids. 1995 Aug 25;77(2):131-7. doi: 10.1016/0009-3084(95)02461-q. PMID: 7586097. 2: Gómez-Merino FC, Brearley CA, Ornatowska M, Abdel-Haliem ME, Zanor MI, Mueller-Roeber B. AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2-dioleoyl- sn-glycerol and exhibits cold-inducible gene expression. J Biol Chem. 2004 Feb 27;279(9):8230-41. doi: 10.1074/jbc.M312187200. Epub 2003 Dec 9. PMID: 14665624. 3: Yashiro K, Kameyama Y, Mizuno-Kamiya M, Shin SO, Fujita A. Microsomal diacylglycerol acyltransferase in rat parotid and submandibular glands: acylation of 1,2-dioleoyl-sn-glycerol dispersed with phospholipids. Int J Biochem Cell Biol. 1996 Aug;28(8):895-903. doi: 10.1016/1357-2725(96)00026-x. PMID: 8811837. 4: Kawasaki T, Snyder F. Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. J Biol Chem. 1988 Feb 25;263(6):2593-6. Erratum in: J Biol Chem 1988 Jul 25;263(21):10539. PMID: 3422635. 5: Welsh CJ, Cabot MC. sn-1,2-diacylglycerols and phorbol diesters: uptake, metabolism, and subsequent assimilation of the diacylglycerol metabolites into complex lipids of cultured cells. J Cell Biochem. 1987 Nov;35(3):231-45. doi: 10.1002/jcb.240350306. PMID: 3693423. 6: Salari H, Low M, Howard S, Edin G, Bittman R. 1-O-hexadecyl-2-O-methyl-sn- glycero-3-phosphocholine inhibits diacylglycerol kinase in WEHI-3B cells. Biochem Cell Biol. 1993 Jan-Feb;71(1-2):36-42. doi: 10.1139/o93-006. PMID: 8392354. 7: Lo SK, Baharin BS, Tan CP, Lai OM. Analysis of 1,2(2,3)- and 1,3-positional isomers of diacylglycerols from vegetable oils by reversed-phase high- performance liquid chromatography. J Chromatogr Sci. 2004 Mar;42(3):145-54. doi: 10.1093/chromsci/42.3.145. PMID: 15023251. 8: Hussein WM, Cheong YS, Liu C, Liu G, Begum AA, Attallah MA, Moyle PM, Torchilin VP, Smith R, Toth I. Peptide-based targeted polymeric nanoparticles for siRNA delivery. Nanotechnology. 2019 Oct 11;30(41):415604. doi: 10.1088/1361-6528/ab313d. Epub 2019 Jul 11. PMID: 31295734. 9: Choi Y, Park JY, Chang PS. Direct and simultaneous analysis of lipase- catalyzed hydrolysis of high-oleic oil model by chiral stationary phase HPLC- ELSD. Food Chem. 2022 Jan 15;367:130750. doi: 10.1016/j.foodchem.2021.130750. Epub 2021 Aug 3. PMID: 34390909. 10: Yu K, McCracken CT Jr, Li R, Hildebrand DF. Diacylglycerol acyltransferases from Vernonia and Stokesia prefer substrates with vernolic acid. Lipids. 2006 Jun;41(6):557-66. doi: 10.1007/s11745-006-5005-x. PMID: 16981434. 11: Wilcox RW, Thuren T, Sisson P, Kucera GL, Waite M. Hydrolysis of neutral lipid substrates by rat hepatic lipase. Lipids. 1991 Apr;26(4):283-8. doi: 10.1007/BF02537138. PMID: 1865764. 12: Rybin VO, Guo J, Gertsberg Z, Feinmark SJ, Steinberg SF. Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolae. J Biol Chem. 2008 Jun 27;283(26):17777-88. doi: 10.1074/jbc.M800333200. Epub 2008 Apr 3. PMID: 18387943; PMCID: PMC2440626. 13: Vallari DS, Record M, Snyder F. Conversion of alkylacetylglycerol to platelet-activating factor in HL-60 cells and subcellular localization of the mediator. Arch Biochem Biophys. 1990 Feb 1;276(2):538-45. doi: 10.1016/0003-9861(90)90756-o. PMID: 2154953. 14: Doherty CM, Tarchala SM, Radwanska E, De Jonge CJ. Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction. J Androl. 1995 Jan-Feb;16(1):36-46. PMID: 7768751. 15: Corrêa ACNTF, Pereira PR, Paschoalin VMF. Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins. J Vis Exp. 2019 Aug 31;(150). doi: 10.3791/59900. PMID: 31524878. 16: Epand RM, Stafford AR, Lester DS. Lipid vesicles which can bind to protein kinase C and activate the enzyme in the presence of EGTA. Eur J Biochem. 1992 Sep 1;208(2):327-32. doi: 10.1111/j.1432-1033.1992.tb17190.x. PMID: 1521529. 17: Corrêa ACNTF, Vericimo MA, Dashevskiy A, Pereira PR, Paschoalin VMF. Liposomal Taro Lectin Nanocapsules Control Human Glioblastoma and Mammary Adenocarcinoma Cell Proliferation. Molecules. 2019 Jan 29;24(3):471. doi: 10.3390/molecules24030471. PMID: 30699910; PMCID: PMC6385085. 18: Lichtenbergova L, Yoon ET, Cho W. Membrane penetration of cytosolic phospholipase A2 is necessary for its interfacial catalysis and arachidonate specificity. Biochemistry. 1998 Oct 6;37(40):14128-36. doi: 10.1021/bi980888s. PMID: 9760249. 19: Dicu AO, Topham MK, Ottaway L, Epand RM. Role of the hydrophobic segment of diacylglycerol kinase epsilon. Biochemistry. 2007 May 22;46(20):6109-17. doi: 10.1021/bi6024726. Epub 2007 Apr 25. PMID: 17455907. 20: Coleman R, Bell RM. Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities. J Biol Chem. 1977 May 10;252(9):3050-6. PMID: 192727.