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MedKoo Cat#: 129013 | Name: T235

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T235 is an Antimalarial agent. T235 provided a complete cure inPlasmodium yoelii-infected mice up to 28 days at doses of 3 and 10mg/kg administered over 4 days and was also curative with a singleoral dose of 20 mg/kg. Furthermore, T235 offered full liver-stageprotection and a sustained blood-stage cure in murine Plasmodiumberghei infection when administered orally at 10 mg/kg/day,exhibiting superior prophylactic efficacy compared to T226.

Chemical Structure

T235
T235
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129013

Name: T235

CAS#: N/A

Chemical Formula: C23H13ClF5NO5

Exact Mass: 513.0402

Molecular Weight: 513.80

Elemental Analysis: C, 53.77; H, 2.55; Cl, 6.90; F, 18.49; N, 2.73; O, 15.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
T235; T 235; T-235
IUPAC/Chemical Name
ethyl 3-chloro-1,7-difluoro-9-oxo-6-(4-(trifluoromethoxy)phenoxy)acridine-10(9H)-carboxylate
InChi Key
AXYVNZFOFLSTBR-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H13ClF5NO5/c1-2-33-22(32)30-17-10-19(34-12-3-5-13(6-4-12)35-23(27,28)29)15(25)9-14(17)21(31)20-16(26)7-11(24)8-18(20)30/h3-10H,2H2,1H3
SMILES Code
FC1=CC(Cl)=CC(N(C(OCC)=O)C2=CC(OC3=CC=C(OC(F)(F)F)C=C3)=C(F)C=C24)=C1C4=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 513.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Morgan T, Craven C, Nelson L, Lalouel JM, Ward K. Angiotensinogen T235 expression is elevated in decidual spiral arteries. J Clin Invest. 1997 Sep 15;100(6):1406-15. doi: 10.1172/JCI119661. PMID: 9294106; PMCID: PMC508319. 2: Fardella CE, Claverie X, Vignolo P, Montero J, Villarroel L. T235 variant of the angiotensinogen gene and blood pressure in the Chilean population. J Hypertens. 1998 Jun;16(6):829-33. doi: 10.1097/00004872-199816060-00014. PMID: 9663923. 3: Katsuya T, Koike G, Yee TW, Sharpe N, Jackson R, Norton R, Horiuchi M, Pratt RE, Dzau VJ, MacMahon S. Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet. 1995 Jun 24;345(8965):1600-3. doi: 10.1016/s0140-6736(95)90115-9. PMID: 7783537. 4: Young RP, Chan JC, Critchley JA, Poon E, Nicholls G, Cockram CS. Angiotensinogen T235 and ACE insertion/deletion polymorphisms associated with albuminuria in Chinese type 2 diabetic patients. Diabetes Care. 1998 Mar;21(3):431-7. doi: 10.2337/diacare.21.3.431. PMID: 9540028. 5: Gallego PH, Shephard N, Bulsara MK, van Bockxmeer FM, Powell BL, Beilby JP, Arscott G, Le Page M, Palmer LJ, Davis EA, Jones TW, Choong CS. Angiotensinogen gene T235 variant: a marker for the development of persistent microalbuminuria in children and adolescents with type 1 diabetes mellitus. J Diabetes Complications. 2008 May-Jun;22(3):191-8. doi: 10.1016/j.jdiacomp.2007.03.003. Epub 2008 Apr 16. PMID: 18413222. 6: Schunkert H, Hense HW, Gimenez-Roqueplo AP, Stieber J, Keil U, Riegger GA, Jeunemaitre X. The angiotensinogen T235 variant and the use of antihypertensive drugs in a population-based cohort. Hypertension. 1997 Feb;29(2):628-33. doi: 10.1161/01.hyp.29.2.628. PMID: 9040449. 7: Pei Y, Scholey J, Thai K, Suzuki M, Cattran D. Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. J Clin Invest. 1997 Aug 15;100(4):814-20. doi: 10.1172/JCI119596. PMID: 9259580; PMCID: PMC508253. 8: Kobashi G, Shido K, Hata A, Yamada H, Kato EH, Kanamori M, Fujimoto S, Kondo K. Multivariate analysis of genetic and acquired factors; T235 variant of the angiotensinogen gene is a potent independent risk factor for preeclampsia. Semin Thromb Hemost. 2001;27(2):143-7. doi: 10.1055/s-2001-14073. PMID: 11372768. 9: Rogus JJ, Moczulski D, Freire MB, Yang Y, Warram JH, Krolewski AS. Diabetic nephropathy is associated with AGT polymorphism T235: results of a family-based study. Hypertension. 1998 Feb;31(2):627-31. doi: 10.1161/01.hyp.31.2.627. PMID: 9461232. 10: Hegele RA, Harris SB, Hanley AJ, Zinman B. Association between AGT T235 variant and microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus. Clin Biochem. 1999 Apr;32(3):201-5. doi: 10.1016/s0009-9120(99)00005-3. PMID: 10383081.