Synonym
Quisultazine; Quisultidina; Quisultidinum;
IUPAC/Chemical Name
N,N-dimethyl-10-(quinuclidin-3-yl)-10H-phenothiazine-2-sulfonamide
InChi Key
HTHHBTMNLHMBHQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25N3O2S2/c1-22(2)28(25,26)16-7-8-21-18(13-16)24(17-5-3-4-6-20(17)27-21)19-14-23-11-9-15(19)10-12-23/h3-8,13,15,19H,9-12,14H2,1-2H3
SMILES Code
O=S(C(C=C1N2C3CN4CCC3CC4)=CC=C1SC5=C2C=CC=C5)(N(C)C)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
415.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wilson JA, Boyd EJ, Wormsley KG. Effects of some polycyclic drugs on gastric secretion and on the healing of duodenal ulcers. Acta Psychiatr Scand Suppl. 1985;320:93-7. PubMed PMID: 2864795.
2: Vatier J, Bessac JF, Bonfils S. The gastric antisecretory activity of a phenothiazine molecule, LM 24056. Arzneimittelforschung. 1982;32(8):815-9. PubMed PMID: 6814453.
3: Kauffmann JM, Patriarche GJ, Viré JC, Heineman WR. Unusual electrochemical behaviour of a new phenothiazine. Analyst. 1985 Apr;110(4):349-51. PubMed PMID: 4025830.
4: Boyd EJ, Wormsley KG. Inhibition of pentagastrin-stimulated and overnight gastric secretion by LM24056, a new phenothiazine-derived antisecretory drug. Lancet. 1981 Feb 28;1(8218):471-3. PubMed PMID: 6110093.
5: Mizoule J, Rataud J, Le Fur G, Jozefczak C, Quarteronet D, Uzan A. On the long acting gastric antisecretory activity of LM 24056 a non H2 antagonist. Life Sci. 1982 Oct 4;31(14):1473-85. PubMed PMID: 7144436.
6: Vatier J, Poitevin C, Vitre MT, Riquet W, Martin P, Bonfils S. The antigastrinic effect of a phenothiazine (LM 24056) prevents gastric secretory activity of histamine. Agents Actions. 1986 Nov;19(3-4):174-9. PubMed PMID: 3103399.
7: Vatier J, Bessac JF, Bonfils S. N,N-dimethyl-10-(3-quinuclidinyl)-2-phenothiazine sulfonamide (LM 24056): mode of action of its gastric antisecretory effect. Arzneimittelforschung. 1983;33(11):1573-6. PubMed PMID: 6140926.
