XC-12 | CD73 Inhibitor

MedKoo Cat#: 128975 | Name: XC-12

Description:

WARNING: This product is for research use only, not for human or veterinary use.

XC-12 is a CD73 Inhibitor for CancerImmunotherapy. XC-12exhibited potent in vitro anti-CD73 activity against both soluble and membrane-bound forms (IC50 = 12.36 and 1.29 nM, respectively). Furthermore, XC-12 was orally bioavailable and significantly inhibited the tumor growth in the CT26 syngeneic mouse model (TGI: 74%) at a dose of 135 mg/kg.

Chemical Structure

XC-12

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128975

Name: XC-12

CAS#: N/A

Chemical Formula: C20H15F3N6O4

Exact Mass: 460.1107

Molecular Weight: 460.37

Elemental Analysis: C, 52.18; H, 3.28; F, 12.38; N, 18.26; O, 13.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

XC-12; XC12; XC 12

IUPAC/Chemical Name

(R)-4-((1-(6-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-oxo-2,3-dihydropyridazin-4-yl)pyrrolidin-3-yl)oxy)-2-(trifluoromethyl)benzonitrile

InChi Key

XANHWKSAPKZIEY-GFCCVEGCSA-N

InChi Code

InChI=1S/C20H15F3N6O4/c21-20(22,23)14-5-11(2-1-10(14)7-24)33-12-3-4-29(9-12)16-6-15(27-28-18(16)31)13-8-25-19(32)26-17(13)30/h1-2,5-6,8,12H,3-4,9H2,(H,28,31)(H2,25,26,30,32)/t12-/m1/s1

SMILES Code

N#CC1=CC=C(O[C@H]2CN(C3=CC(C4=CNC(NC4=O)=O)=NNC3=O)CC2)C=C1C(F)(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 460.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang K, Tang J, Wang Y, Kang H, Zeng J. The tolerance to saline-alkaline stress was dependent on the roots in wheat. Physiol Mol Biol Plants. 2020 May;26(5):947-954. doi: 10.1007/s12298-020-00799-x. Epub 2020 Apr 20. PMID: 32377044; PMCID: PMC7196563. 2: Cen L, Ren W, Yu J, Cheng M, Kong X, Yan W, Wang L, Li X, Liu J, Wang Z, Wu S, Sun X, Wei P, Gu H, Zhu Q, Zou Y, Xu Y. Discovery of Orally Potent Small- Molecule CD73 Inhibitor for Cancer Immunotherapy. J Med Chem. 2025 May 23. doi: 10.1021/acs.jmedchem.5c00035. Epub ahead of print. PMID: 40409990.