T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 µM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
MedKoo Cat#: 464825
Name: T-5342126
CAS#: 956507-49-6
Chemical Formula: C25H32ClN3O3
Exact Mass: 457.2132
Molecular Weight: 458.00
Elemental Analysis: C, 65.56; H, 7.04; Cl, 7.74; N, 9.17; O, 10.48
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| Methyl Acetate | 10.0 | 21.83 |
The following data is based on the product molecular weight 458.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
