RP-1664 is a novel selective PLK4 inhibitor. RP-1664 that both centriole loss and amplification contribute to hypersensitivity of neuroblastoma cells. Whereas inactivation of TRIM37 and TP53 rescues neuroblastoma cell death at higher concentrations of RP-1664, at lower doses cell death is TRIM37/TP53-independent. In vivo, RP-1664 shows robust efficacy in neuroblastoma xenografts at doses consistent with centriole amplification.
MedKoo Cat#: 128918
Name: RP-1664
CAS#: N/A
Chemical Formula: C23H24F2N8O2S
Exact Mass: 514.1711
Molecular Weight: 514.56
Elemental Analysis: C, 53.69; H, 4.70; F, 7.38; N, 21.78; O, 6.22; S, 6.23
The following data is based on the product molecular weight 514.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
