GFH009 | CDK9 inhibitor

MedKoo Cat#: 128799 | Name: GFH009

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GFH009 is a CDK9 inhibitor.

Chemical Structure

GFH009

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128799

Name: GFH009

CAS#: N/A

Chemical Formula: C25H35ClN6O2S

Exact Mass: 518.2231

Molecular Weight: 519.11

Elemental Analysis: C, 57.84; H, 6.80; Cl, 6.83; N, 16.19; O, 6.16; S, 6.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GFH009; GFH 009; GFH-009

IUPAC/Chemical Name

4-(((4-(5-chloro-2-(((1R,4r)-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

InChi Key

PGVNLOUNSPQGJP-GUDVDZBRSA-N

InChi Code

InChI=1S/C25H35ClN6O2S/c1-17(13-33-2)30-18-3-5-19(6-4-18)31-23-11-20(21(26)12-28-23)22-14-35-24(32-22)29-16-25(15-27)7-9-34-10-8-25/h11-12,14,17-19,30H,3-10,13,16H2,1-2H3,(H,28,31)(H,29,32)/t17-,18-,19-/m1/s1

SMILES Code

COC[C@@H](C)N[C@@H]1CC[C@@H](NC2=NC=C(Cl)C(C3=CSC(NCC4(C#N)CCOCC4)=N3)=C2)CC1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 519.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhou F, Tang L, Le S, Ge M, Cicic D, Xie F, Ren J, Lan J, Lu Q. The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies. Oncotarget. 2023 Dec 20;14:997-1008. doi: 10.18632/oncotarget.28543. PMID: 38117531; PMCID: PMC10732257. 2: Wang L, Zhao JZ, Zhou FS, Lan J, Lu Q, Ren HC. Preclinical metabolism and disposition of [¹⁴C]GFH009, a novel selective CDK9 inhibitor. Xenobiotica. 2024 Oct;54(10):831-839. doi: 10.1080/00498254.2024.2428716. Epub 2024 Nov 15. PMID: 39526731. 3: Liu Q, Zhao JZ, Zhou FS, Lan J, Lu Q, Ren HC. Development and validation of a sensitive UPLC-MS/MS analytical method for GFH009 in rat plasma and its application to toxicokinetics studies. Biomed Chromatogr. 2024 Feb;38(2):e5788. doi: 10.1002/bmc.5788. Epub 2023 Dec 11. PMID: 38081587.