MedKoo Cat#: 533143 | Name: CRBN-6-5-5-VHL
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CRBN-6-5-5-VHL is a novel cell-permeable, potent and selective cereblon degrader.

Chemical Structure

CRBN-6-5-5-VHL
CRBN-6-5-5-VHL
CAS#2362575-45-7

Theoretical Analysis

MedKoo Cat#: 533143

Name: CRBN-6-5-5-VHL

CAS#: 2362575-45-7

Chemical Formula: C51H69N7O10S

Exact Mass: 971.4827

Molecular Weight: 972.21

Elemental Analysis: C, 63.01; H, 7.15; N, 10.09; O, 16.46; S, 3.30

Price and Availability

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5mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
CRBN-6-5-5-VHL
IUPAC/Chemical Name
(2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key
LIMCHOLAKDUZDS-XARBDFOFSA-N
InChi Code
InChI=1S/C51H69N7O10S/c1-33-44(69-32-54-33)35-20-18-34(19-21-35)30-53-46(62)40-29-36(59)31-57(40)50(66)45(51(2,3)4)55-41(60)17-8-13-28-68-27-12-7-11-26-67-25-10-6-5-9-24-52-38-16-14-15-37-43(38)49(65)58(48(37)64)39-22-23-42(61)56-47(39)63/h14-16,18-21,32,36,39-40,45,52,59H,5-13,17,22-31H2,1-4H3,(H,53,62)(H,55,60)(H,56,61,63)/t36-,39?,40+,45-/m1/s1
SMILES Code
O=C([C@H]1N(C([C@@H](NC(CCCCOCCCCCOCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Appearance
Solid powder
Purity
>96% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 972.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL