GFB-12811 is a potent and selective CDK5 inhibitor (IC50 = 2.3 nM). In cellular assays, GFB-12811 demonstrate CDK5 target engagement while avoiding antiproliferative effects associated with inhibiting other CDKs. In addition, GFB-12811 exhibit promising in vivo PK profiles, enabling their use as tool compounds for interrogating the role of CDK5 in ADPKD and other diseases.
MedKoo Cat#: 465803
Name: GFB-12811
CAS#: unknown
Chemical Formula: C22H23F4N5O
Exact Mass: 449.1839
Molecular Weight: 449.45
Elemental Analysis: C, 58.79; H, 5.16; F, 16.91; N, 15.58; O, 3.56
The following data is based on the product molecular weight 449.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
