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MedKoo Cat#: 464680 | Name: GHCA-d4
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glycohyocholic Acid-d4 (GHCA-d4) is intended for use as an internal standard for the quantification of GHCA by GC- or LC-MS. GHCA is a glycine-conjugated form of the primary bile acid hyocholic acid. GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls. Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.

Chemical Structure

GHCA-d4
GHCA-d4
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464680

Name: GHCA-d4

CAS#: unknown

Chemical Formula: C26H39D4NO6

Exact Mass: 469.3341

Molecular Weight: 469.66

Elemental Analysis: C, 66.49; H, 10.09; N, 2.98; O, 20.44

Price and Availability

Size Price Availability Quantity
1mg USD 465.00 2 Weeks
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Related CAS #
No Data
Synonym
Glycohyocholic Acid-d4; Glycohyocholic Acid d4; GHCA-d4; GHCA d4; Glycine Hyocholate-d4; Glycohyocholate-d4;
IUPAC/Chemical Name
((R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl-2,2,4,4-d4)pentanoyl)glycine
InChi Key
ZQYUKJFJPJDMMR-FWCDZUIRSA-N
InChi Code
InChI=1S/C26H43NO6/c1-14(4-7-20(29)27-13-21(30)31)16-5-6-17-22-18(9-11-25(16,17)2)26(3)10-8-15(28)12-19(26)23(32)24(22)33/h14-19,22-24,28,32-33H,4-13H2,1-3H3,(H,27,29)(H,30,31)/t14-,15-,16-,17+,18+,19+,22+,23-,24+,25-,26-/m1/s1/i8D2,12D2
SMILES Code
O[C@@H]1C([2H])(C[C@]2([C@@]([H])(C1([2H])[2H])[C@H]([C@H]([C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@@]4([C@@H](CCC(NCC(O)=O)=O)C)[H])[H])C)[H])[H])O)O)C)[2H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 30.0 63.87
DMF:PBS (pH 7.2) (1:1) 0.5 1.06
DMSO 20.0 42.58
Ethanol 20.0 42.58
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 469.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Grzych G, Chávez-Talavera O, Descat A, Thuillier D, Verrijken A, Kouach M, Legry V, Verkindt H, Raverdy V, Legendre B, Caiazzo R, Van Gaal L, Goossens JF, Paumelle R, Francque S, Pattou F, Haas JT, Tailleux A, Staels B. NASH-related increases in plasma bile acid levels depend on insulin resistance. JHEP Rep. 2020 Dec 16;3(2):100222. doi: 10.1016/j.jhepr.2020.100222. PMID: 33615207; PMCID: PMC7878982. 2: Schjødt MS, Gürdeniz G, Chawes B. The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review. Metabolites. 2020 Dec 16;10(12):511. doi: 10.3390/metabo10120511. PMID: 33339279; PMCID: PMC7767195. 3: Kühn T, Stepien M, López-Nogueroles M, Damms-Machado A, Sookthai D, Johnson T, Roca M, Hüsing A, Maldonado SG, Cross AJ, Murphy N, Freisling H, Rinaldi S, Scalbert A, Fedirko V, Severi G, Boutron-Ruault MC, Mancini FR, Sowah SA, Boeing H, Jakszyn P, Sánchez MJ, Merino S, Colorado-Yohar S, Barricarte A, Khaw KT, Schmidt JA, Perez-Cornago A, Trichopoulou A, Karakatsani A, Thriskos P, Palli D, Agnoli C, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita B, van Gils CH, Heath AK, Gunter MJ, Riboli E, Lahoz A, Jenab M, Kaaks R. Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study. J Natl Cancer Inst. 2020 May 1;112(5):516-524. doi: 10.1093/jnci/djz166. Erratum in: J Natl Cancer Inst. 2020 Oct 1;112(10):1077. PMID: 31435679; PMCID: PMC7225675. 4: He J, Li J, Sun W, Zhang T, Ito Y. PREPARATIVE ISOLATION AND PURIFICATION OF THREE GLYCINE-CONJUGATED CHOLIC ACIDS FROM PULVIS FELLIS SUIS BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY COUPLED WITH ELSD DETECTION. J Liq Chromatogr Relat Technol. 2012;35(5):737-746. doi: 10.1080/10826076.2011.608231. Epub 2012 Feb 22. PMID: 23008527; PMCID: PMC3448131. 5: Foley DP, Collins BR, Magee JC, Platt JL, Katz E, Harland RC, Meyers WC, Chari RS. Bile acids in xenogeneic ex-vivo liver perfusion: function of xenoperfused livers and compatibility with human bile salts and porcine livers. Transplantation. 2000 Jan 27;69(2):242-8. doi: 10.1097/00007890-200001270-00009. PMID: 10670634.