MedKoo Cat#: 464082 | Name: AY77

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AY77 is a Potent protease activated receptor 2 (PAR2) calcium-biased agonist (EC50 40 nM, Ca2+; EC50 2 µM, ERK1/2).

Chemical Structure

AY77
AY77
CAS#1835734-92-3

Theoretical Analysis

MedKoo Cat#: 464082

Name: AY77

CAS#: 1835734-92-3

Chemical Formula: C21H32N4O4

Exact Mass: 404.2424

Molecular Weight: 404.51

Elemental Analysis: C, 62.35; H, 7.97; N, 13.85; O, 15.82

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Synonym
AY77; AY 77; AY-77; Isox-Cha-Chg-NH2;
IUPAC/Chemical Name
N-((S)-1-(((S)-2-amino-1-cyclohexyl-2-oxoethyl)amino)-3-cyclohexyl-1-oxopropan-2-yl)isoxazole-5-carboxamide
InChi Key
CAYJNBJPGBBDAS-WMZOPIPTSA-N
InChi Code
InChI=1S/C21H32N4O4/c22-19(26)18(15-9-5-2-6-10-15)25-20(27)16(13-14-7-3-1-4-8-14)24-21(28)17-11-12-23-29-17/h11-12,14-16,18H,1-10,13H2,(H2,22,26)(H,24,28)(H,25,27)/t16-,18-/m0/s1
SMILES Code
O=C(C1=CC=NO1)N[C@@H](CC2CCCCC2)C(N[C@@H](C3CCCCC3)C(N)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 404.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jiang Y, Yau MK, Kok WM, Lim J, Wu KC, Liu L, Hill TA, Suen JY, Fairlie DP. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. doi: 10.1021/acschembio.6b01088. Epub 2017 Mar 14. PMID: 28169521. 2: Ando A, Nakamura T. Prevention of GABA reduction during dough fermentation using a baker's yeast dal81 mutant. J Biosci Bioeng. 2016 Oct;122(4):441-5. doi: 10.1016/j.jbiosc.2016.03.006. Epub 2016 Apr 4. PMID: 27056577.