Synonym
PA21A050; PA21A-050; PA21-A050
IUPAC/Chemical Name
N-(4-(4-chloro-2-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)acetamide
InChi Key
OLMXEDHUPRLENN-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H20ClF4N5O/c1-12(2)21-29-16-6-4-5-7-17(16)33(21)11-18(34)30-22-19(14-9-8-13(24)10-15(14)25)20(23(26,27)28)31-32(22)3/h4-10,12H,11H2,1-3H3,(H,30,34)
SMILES Code
CN1N=C(C(F)(F)F)C(C2=CC=C(Cl)C=C2F)=C1NC(CN3C(C(C)C)=NC4=C3C=CC=C4)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
493.89
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Maron MI, Magle CT, Czesny B, Turturice BA, Huang R, Zheng W, Vaidya AB,
Williamson KC. Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates
the Gametocytocidal Activity of the Pyrazoleamide PA21A050. Antimicrob Agents
Chemother. 2015 Dec 28;60(3):1492-9. doi: 10.1128/AAC.01928-15. PMID: 26711768;
PMCID: PMC4775975.
2: Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, Otto TD, Spillman NJ,
Wyvratt M, Siegl P, Marfurt J, Wirjanata G, Sebayang BF, Price RN, Chatterjee A,
Nagle A, Stasiak M, Charman SA, Angulo-Barturen I, Ferrer S, Belén Jiménez-Díaz
M, Martínez MS, Gamo FJ, Avery VM, Ruecker A, Delves M, Kirk K, Berriman M,
Kortagere S, Burrows J, Fan E, Bergman LW. Pyrazoleamide compounds are potent
antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium
falciparum. Nat Commun. 2014 Nov 25;5:5521. doi: 10.1038/ncomms6521. PMID:
25422853; PMCID: PMC4263321.
