MedKoo Cat#: 128788 | Name: JS1310

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JS1310 is PRMT7 inhibitor.

Chemical Structure

JS1310
JS1310
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128788

Name: JS1310

CAS#: N/A

Chemical Formula: C23H22FN5O3

Exact Mass: 435.1707

Molecular Weight: 435.46

Elemental Analysis: C, 63.44; H, 5.09; F, 4.36; N, 16.08; O, 11.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JS1310; JS-1310; JS 1310
IUPAC/Chemical Name
N6-(5-fluoro-2-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl)-2-methylquinoline-4,6-diamine
InChi Key
DJRAKTLQKMVYOK-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22FN5O3/c1-12-7-17(25)15-10-14(5-6-18(15)27-12)28-23-16(24)11-26-22(29-23)13-8-19(30-2)21(32-4)20(9-13)31-3/h5-11H,1-4H3,(H2,25,27)(H,26,28,29)
SMILES Code
COC1=C(OC)C=C(C2=NC=C(F)C(NC3=CC=C(N=C(C)C=C4N)C4=C3)=N2)C=C1OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 435.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liu C, Zou W, Nie D, Li S, Duan C, Zhou M, Lai P, Yang S, Ji S, Li Y, Mei M, Bao S, Jin Y, Pan J. Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML. Cell Metab. 2022 Jun 7;34(6):818-835.e7. doi: 10.1016/j.cmet.2022.04.004. Epub 2022 May 3. PMID: 35508169.