Jtp 2942 | CAS#148152-77-6 | thyrotropin-releasing hormone analogue

MedKoo Cat#: 597834 | Name: Jtp 2942

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Jtp 2942 is a novel thyrotropin-releasing hormone analogue.

Chemical Structure

Jtp 2942

CAS#148152-77-6

Theoretical Analysis

MedKoo Cat#: 597834

Name: Jtp 2942

CAS#: 148152-77-6

Chemical Formula: C18H25N5O4

Exact Mass: 375.1907

Molecular Weight: 375.42

Elemental Analysis: C, 57.59; H, 6.71; N, 18.65; O, 17.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Jtp 2942; Jtp-2942; Jtp2942;

IUPAC/Chemical Name

(S)-1-(((S)-1-methyl-3-oxocyclopentane-1-carbonyl)-L-histidyl)pyrrolidine-2-carboxamide

InChi Key

QATMSFATAIOXJC-DEYYWGMASA-N

InChi Code

InChI=1S/C18H25N5O4/c1-18(5-4-12(24)8-18)17(27)22-13(7-11-9-20-10-21-11)16(26)23-6-2-3-14(23)15(19)25/h9-10,13-14H,2-8H2,1H3,(H2,19,25)(H,20,21)(H,22,27)/t13-,14-,18-/m0/s1

SMILES Code

O=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@@]3(C)CCC(C3)=O)=O)=O)CCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 375.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ikeda K, Iwasaki Y, Kinoshita M. JTP-2942, a novel thyrotropin-releasing hormone analogue, protects against spinal motor neuron degeneration in the wobbler mouse. Neurosci Lett. 1998 Jun 26;250(1):9-12. PubMed PMID: 9696053. 2: Matsushita M, Yonemori F, Hamada A, Toide K, Iwata K. Effect of JTP-2942, a novel thyrotropin-releasing hormone analogue, on pentobarbital-induced anesthesia in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):177-82. PubMed PMID: 7781687. 3: Katsumata T, Katayama Y, Yonemori H, Muramatsu H, Otori T, Nishiyama Y, Yamada H, Nakamura H, Terashi A. Delayed administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, improves cerebral blood flow and metabolism in rat postischaemic brain. Clin Exp Pharmacol Physiol. 2001 Jan-Feb;28(1-2):48-54. PubMed PMID: 11153536. 4: Urayama A, Yamada S, Deguchi Y, Kimura R, Maeda Y, Kobayashi T. Brain receptor binding characteristics and pharmacokinetics of JTP-2942, a novel thyrotropin-releasing hormone (TRH) analogue. Life Sci. 1999;65(22):2407-15. PubMed PMID: 10597895. 5: Katsumata T, Katayama Y, Ootori T, Muramatsu H, Nishiyama Y, Nakamura H, Seta T, Terashi A. Effect of long-term administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, on neurological outcome, local cerebral blood flow and glucose utilization in a rat focal cerebral ischemia. Brain Res. 2001 May 18;901(1-2):62-70. PubMed PMID: 11368951. 6: Toide K, Shinoda M, Takase M, Iwata K, Yoshida H. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. Eur J Pharmacol. 1993 Mar 16;233(1):21-8. PubMed PMID: 8472746. 7: Yonemori F, Yamaguchi T, Nakayama H, Narita K, Hojo S, Tamura A. Effect of JTP-2942, a novel thyrotropin-releasing hormone analog, on motor deficits after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Jan;20(1):74-81. PubMed PMID: 10616795. 8: Matsushita M, Yonemori F, Ohta A, Iwata K. Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. Arzneimittelforschung. 1995 Jun;45(6):708-11. PubMed PMID: 7646576. 9: Matsushita M, Yonemori F, Furukawa N, Ohta A, Toide K, Uchida I, Iwata K. Effects of the novel thyrotropin-releasing hormone analogue Na -((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prol ina mide monohydrate on the central nervous system in mice and rats. Arzneimittelforschung. 1993 Aug;43(8):813-7. PubMed PMID: 8216433.