MedKoo Cat#: 146176 | Name: Tussilagine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tussilagine is a natural alkaloid compound found in plants such as Tussilago farfara (coltsfoot), which has traditionally been used to treat respiratory ailments. It exhibits bronchodilator, anti-inflammatory, and antitussive properties, making it effective for relieving coughs, bronchitis, and other respiratory conditions. Tussilagine works by relaxing the smooth muscles of the airways, reducing inflammation, and soothing the throat, which helps alleviate coughing and improve breathing. Its mechanism involves the inhibition of inflammatory mediators and the enhancement of lung function, providing symptomatic relief for respiratory issues.

Chemical Structure

Tussilagine
Tussilagine
CAS#80151-77-5

Theoretical Analysis

MedKoo Cat#: 146176

Name: Tussilagine

CAS#: 80151-77-5

Chemical Formula: C10H17NO3

Exact Mass: 199.1208

Molecular Weight: 199.25

Elemental Analysis: C, 60.28; H, 8.60; N, 7.03; O, 24.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tussilagine;
IUPAC/Chemical Name
methyl (1S,2S,7aS)-2-hydroxy-2-methylhexahydro-1H-pyrrolizine-1-carboxylate
InChi Key
LADVYSUMGRTFSZ-QXFUBDJGSA-N
InChi Code
1S/C10H17NO3/c1-10(13)6-11-5-3-4-7(11)8(10)9(12)14-2/h7-8,13H,3-6H2,1-2H3/t7-,8+,10+/m0/s1
SMILES Code
COC(=O)[C@H]1[C@@H]2CCCN2C[C@@]1(C)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 199.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Paßreiter CM, Willuhn G, Röder E. Tussilagine and isotussilagine: two pyrrolizidine alkaloids in the genus arnica1. Planta Med. 1992 Dec;58(6):556-7. doi: 10.1055/s-2006-961549. PMID: 17226521. 2: Röder E, Wiedenfeld H, Jost EJ. Tussilagin - ein neues Pyrrolizidinalkaloid aus Tussilago farfara [Tussilagine - a new pyrrolizidine alkaloid from Tussilago farfara]. Planta Med. 1981 Sep;43(1):99-102. German. doi: 10.1055/s-2007-971485. PMID: 17402021. 3: Zündorf I, Wiedenfeld H, Röder E, Dingermann T. Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine. Planta Med. 1998 Apr;64(3):259-63. doi: 10.1055/s-2006-957421. PMID: 9581524.