TK-685 is a potent and selective allosteric SHP2 inhibitor with SHP2WT IC50 =1.5 nM; Ki = 0.87 nM), likely binding to the “tunnel” allosteric site of SHP2. By targeting SHP2-mediated AKT and ERK signaling pathways, TK-685 suppressed cell proliferation and induced apoptosis in esophageal cancer cells. Additionally, oral administration of TK-685 demonstrated good antitumor effects in the KYSE-150 xenograft mouse model, with a T/C value of 76.8%.
MedKoo Cat#: 128778
Name: TK-685
CAS#: N/A
Chemical Formula: C18H20Cl2N6OS
Exact Mass: 438.0796
Molecular Weight: 439.36
Elemental Analysis: C, 49.21; H, 4.59; Cl, 16.14; N, 19.13; O, 3.64; S, 7.30
The following data is based on the product molecular weight 439.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
