Hematin | CAS#15489-90-4 | Iron-containing Porphyrin

MedKoo Cat#: 561572 | Name: Hematin

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hematin is a porphyrin-based heme derivative formed by the oxidation of ferrous heme (Fe²⁺) to ferric heme (Fe³⁺), playing a crucial role in heme metabolism and detoxification. It acts as an allosteric inhibitor of 5-aminolevulinate synthase (ALAS1), regulating heme biosynthesis and serving as a treatment for acute porphyria attacks. Additionally, hematin can interact with malarial hemozoin formation, contributing to the mechanism of action of certain antimalarial drugs like chloroquine.

Chemical Structure

Hematin

CAS#15489-90-4

Theoretical Analysis

MedKoo Cat#: 561572

Name: Hematin

CAS#: 15489-90-4

Chemical Formula: C34H33FeN4O5

Exact Mass: 633.1800

Molecular Weight: 633.50

Elemental Analysis: C, 64.46; H, 5.25; Fe, 8.82; N, 8.84; O, 12.63

Price and Availability

Size	Price	Availability
1g	USD 350.00	2 Weeks
5g	USD 750.00	2 Weeks
10g	USD 1,050.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Hematin; Ferrihemate; Ferriheme; Ferriheme hydroxide; Ferrihemic acid

IUPAC/Chemical Name

3-[18-(2-Carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid iron(2+) hydroxide

InChi Key

BMUDPLZKKRQECS-HXFTUNQESA-K

InChi Code

InChI=1S/C34H34N4O4.Fe.H2O/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);;1H2/q;+3;/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

SMILES Code

CC1=C(C=C2C(C)=C(C=C)C3=[N]2[Fe]45(O)N6C(C(C)=C(C=C)C6=C7)=C3)N4C(C=C8[N]5=C7C(C)=C8CCC(O)=O)=C1CCC(O)=O

Appearance

Solid powder

Purity

>90% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 633.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chen Y, Lv B, Wang W, Wu Y, Li D. Structure-switching G-quadruplex: An efficient CRISPR/Cas12a signal reporter for label-free colorimetric biosensing. Int J Biol Macromol. 2025 Mar 21:142410. doi: 10.1016/j.ijbiomac.2025.142410. Epub ahead of print. PMID: 40122420. 2: Martínez-Ávila MC, Matijasevic-Arcila E, Pantoja-Chica S, Acosta-Cardozo AL. Characterizing hepatic porphyria: Insights from a quaternary care hospital in Bogotá, Colombia (2013-2023). J Int Med Res. 2025 Mar;53(3):3000605251325183. doi: 10.1177/03000605251325183. Epub 2025 Mar 21. PMID: 40116802; PMCID: PMC11930460. 3: Aliouat H, Zhang D, Peng L, Huang J, Cheng H, Zhu J, Chen X, Xie N, Zhou W, Zhao S. Targeted DNA Nanomachine Enables Specific miRNA-Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy. Adv Sci (Weinh). 2025 Mar 21:e2415296. doi: 10.1002/advs.202415296. Epub ahead of print. PMID: 40116278. 4: Nayak D, Mishra AK, Biswas K, Sen A, Malakar C, Panda J, Kungwani NA, Rustagi S, Panda BP, Mohanta YK. Mangrove pneumatophores as biocatalysts for the fabrication of silver nanoparticles and their potential applications against biofilm formation and hepatic carcinoma. Nanoscale Adv. 2025 Mar 3. doi: 10.1039/d4na00722k. Epub ahead of print. PMID: 40104604; PMCID: PMC11912619. 5: Zhou H, Zhu C, Li Y, Zhao F, Feng Q, Liu S, Jia S, Ji J, Ye L, Zhai G, Yang X. Exosome/liposome hybrid nanovesicles for enhanced phototherapy and boosted anti-tumor immunity against melanoma. Eur J Med Chem. 2025 Mar 8;289:117485. doi: 10.1016/j.ejmech.2025.117485. Epub ahead of print. PMID: 40081104. 6: Cai Y, Zhang Y, Liang X, Deng C, Zhang J, Wang H, Duan H, Yao Y. A water- soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host-guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy. Chem Commun (Camb). 2025 Mar 13. doi: 10.1039/d5cc00627a. Epub ahead of print. PMID: 40080379. 7: Liu HH, Yang F, Zhang L, Zhang XL, Zhao N, Zhang ZY, Zhou JB, Wei TP, Qian LL, Ding LG, Wang RX. Decreased PLK2 promotes atrial fibrillation in diabetic mice through Nrf2/HO-1 pathway. Acta Diabetol. 2025 Mar 13. doi: 10.1007/s00592-025-02480-9. Epub ahead of print. PMID: 40080197. 8: Zhang Z, Wang J, Guo S, Wang X. C-ZIF-8 modified NiO photocathode and enhanced photosensitizer signal amplification for ultra-sensitive photoelectrochemical detection of lead ions. Anal Methods. 2025 Mar 13. doi: 10.1039/d5ay00136f. Epub ahead of print. PMID: 40079518. 9: Choi H, Yanagita M, Teramoto Y, Takano T. Preparation of hemin-bound chitosan flakes and their dye decolorizing ability. Int J Biol Macromol. 2025 Mar 10;307(Pt 1):141952. doi: 10.1016/j.ijbiomac.2025.141952. Epub ahead of print. PMID: 40074110. 10: Xu Y, Ren M, Deng R, Meng J, Xu L, Zhao W, Ni Y, Mao C, Zhang S. UCNPs@PVP- Hemin-GOx@CaCO3 Nanoplatform for Ferroptosis Self-Amplification Combined with Calcium Overload. Adv Healthc Mater. 2025 Mar 12:e2404215. doi: 10.1002/adhm.202404215. Epub ahead of print. PMID: 40072332. 11: Zhang L, Wang X, Zhou S, Feng Y. LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. Brain Res Bull. 2025 Mar 6;224:111292. doi: 10.1016/j.brainresbull.2025.111292. Epub ahead of print. PMID: 40057050. 12: Ren Y, Dong Y, Li Z, Xu K, Xu J, Li X, Zhang M, Xu C, Yang M, Lee M, Meng X, Wang J. Kidney-targeting DNA tetrahedral molecular cage synergistically inhibits acute kidney injury by clearing ROS and activating HO-1. Biomaterials. 2025 Mar 3;320:123237. doi: 10.1016/j.biomaterials.2025.123237. Epub ahead of print. PMID: 40049024. 13: Shen Y, Wang Y, Liu F. Eupatilin mitigates ICH-induced brain injury via SOX2/SLC7A11 regulation of ferroptosis. Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 6. doi: 10.1007/s00210-025-03928-z. Epub ahead of print. PMID: 40047856. 14: Jia G, Yang X, Yu Y, Li Y, Zhang Z, Tang X, Wang Q, Zheng H, Xiao Y, Li S, Wang Y. Quercetin carbon quantum dots: dual-target therapy for intracerebral hemorrhage in mice. Mol Brain. 2025 Mar 3;18(1):17. doi: 10.1186/s13041-024-01159-6. PMID: 40033442; PMCID: PMC11874443. 15: Lei L, Chen X, Long X, Tu Q, Zhao L, Huang D, Song L, Wang J, Zhai S, Chen X, Zhang C. Z/Ce@hemin enzymes with enhanced peroxidase activity for monitoring and screening the oxidative stress models of Parkinson's disease. NPJ Parkinsons Dis. 2025 Mar 1;11(1):37. doi: 10.1038/s41531-025-00875-7. PMID: 40025049; PMCID: PMC11873119. 16: Tanabe T, Miyamoto K, Nagaoka K, Tsujibo H, Funahashi T. Effect of (p)ppGpp on the Expression of the Vibrioferrin-Mediated Iron Acquisition System in Vibrio parahaemolyticus. Biol Pharm Bull. 2025;48(2):188-194. doi: 10.1248/bpb.b24-00624. PMID: 40024720. 17: Wagner MEU, Frost M, Frystyk J. Acute hepatic porphyria in Denmark; a retrospective study. Orphanet J Rare Dis. 2025 Feb 28;20(1):93. doi: 10.1186/s13023-025-03536-3. PMID: 40022110; PMCID: PMC11871779. 18: Zhang H, Yang T, Mu W, Peng X, Liu T, Weng L, Wang H, Zhang Y, Chen X. Effective Amplification of Oxidative Stress and Calcium Manipulation Mediated Mitochondrial Dysfunction Based on Engineered Nanozyme for Primary and Metastatic Breast Cancer Therapy. Small. 2025 Feb 28:e2411299. doi: 10.1002/smll.202411299. Epub ahead of print. PMID: 40018887. 19: Xiaoqian F, Hemin L. Successful rivaroxaban and doxycycline therapy for Mycoplasma pneumonia with pulmonary embolism in children: a case report. Front Pediatr. 2025 Feb 12;13:1449493. doi: 10.3389/fped.2025.1449493. PMID: 40013116; PMCID: PMC11861191. 20: Cahyadi O, Ewald P, Quast D, Siau K, Uhl W, Schmidt W, Torres Reyes C. Ingestible sensor capsule with extended battery capacity allows early diagnosis of GI malignancy in comorbid patients with occult bleeding and anemia. Endosc Int Open. 2025 Jan 7;13:a24749966. doi: 10.1055/a-2474-9966. PMID: 40012575; PMCID: PMC11863541.