Calmagite | CAS#3147-14-6 | indicator

MedKoo Cat#: 146267 | Name: Calmagite

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Calmagite is a complexometric indicator commonly used in analytical chemistry to detect metal ions, particularly calcium and magnesium, in solution. It functions by forming colored complexes with these metal ions, which leads to a visible color change that can be used to determine their concentration during titrations, such as in water hardness testing. The dye changes from red to blue depending on whether it is bound to metal ions or not, making it an effective visual indicator.

Chemical Structure

Calmagite

CAS#3147-14-6

Theoretical Analysis

MedKoo Cat#: 146267

Name: Calmagite

CAS#: 3147-14-6

Chemical Formula: C17H14N2O5S

Exact Mass: 358.0623

Molecular Weight: 358.37

Elemental Analysis: C, 56.98; H, 3.94; N, 7.82; O, 22.32; S, 8.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Calmagite;

IUPAC/Chemical Name

(E)-3-hydroxy-4-((2-hydroxy-5-methylphenyl)diazenyl)naphthalene-1-sulfonic acid

InChi Key

VBRNLOQCBCPPHL-VHEBQXMUSA-N

InChi Code

1S/C17H14N2O5S/c1-10-6-7-14(20)13(8-10)18-19-17-12-5-3-2-4-11(12)16(9-15(17)21)25(22,23)24/h2-9,20-21H,1H3,(H,22,23,24)/b19-18+

SMILES Code

CC1=CC=C(O)C(=C1)\N=N\C2=C3C=CC=CC3=C(C=C2O)S(O)(=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 358.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lindstrom F, Isaac R. Crystalline calmagite and a study of sulphonation effects on azo dye metal-ion indicators. Talanta. 1966 Jul;13(7):1003-11. doi: 10.1016/0039-9140(66)80199-6. PMID: 18959965. 2: Singhal I, Arora M, Dave A, Bansal SK, Saluja P, Rai R. Evaluation of magnesium levels in serum and saliva by calmagite method in individuals with tobacco habits with or without potentially malignant disorders. J Oral Maxillofac Pathol. 2023 Apr-Jun;27(2):425. doi: 10.4103/jomfp.jomfp_119_22. Epub 2023 Jul 13. PMID: 37854910; PMCID: PMC10581312. 3: Woodward C, Freiser H. Calmagite as a spectrophotometric reagent for aluminium. Talanta. 1968 Mar;15(3):321-5. doi: 10.1016/0039-9140(68)80062-1. PMID: 18960299. 4: Cao Y, Sheriff TS. The oxidative degradation of Calmagite using added and in situ generated hydrogen peroxide catalysed by manganese(II) ions: Efficacy evaluation, kinetics study and degradation pathways. Chemosphere. 2022 Jan;286(Pt 2):131792. doi: 10.1016/j.chemosphere.2021.131792. Epub 2021 Aug 6. PMID: 34388875. 5: Ye SW, Song SD, Liu XJ, Luo Y, Cai SQ. A small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway. Aging Cell. 2025 Mar;24(3):e14411. doi: 10.1111/acel.14411. Epub 2024 Nov 18. PMID: 39552540; PMCID: PMC11896485. 6: Rasouli Z, Ghavami R. Simultaneously detection of calcium and magnesium in various samples by calmagite and chemometrics data processing. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Dec 5;169:72-81. doi: 10.1016/j.saa.2016.06.027. Epub 2016 Jun 18. PMID: 27341399. 7: Chauhan UP, Sarkar BC. Use of calmagite for the determination of traces of magnesium in biological materials. Anal Biochem. 1969 Oct 15;32(1):70-80. doi: 10.1016/0003-2697(69)90105-5. PMID: 5398269. 8: Agarwal S, Cluxton P, Kemper M, Dionysiou DD, Al-Abed SR. Assessment of the functionality of a pilot-scale reactor and its potential for electrochemical degradation of calmagite, a sulfonated azo-dye. Chemosphere. 2008 Oct;73(5):837-43. doi: 10.1016/j.chemosphere.2008.06.050. Epub 2008 Aug 3. PMID: 18676003. 9: Sheriff TS, Cope S, Ekwegh M. Calmagite dye oxidation using in situ generated hydrogen peroxide catalysed by manganese(II) ions. Dalton Trans. 2007 Nov 28;(44):5119-22. doi: 10.1039/b711143f. Epub 2007 Oct 4. PMID: 17985017. 10: Cohen SA, Daza IE. Calmagite method for determination of serum magnesium modified. Clin Chem. 1980 May;26(6):783. PMID: 7371163. 11: Soury R, Jabli M, Saleh TA, Abdul-Hassan WS, Saint-Aman E, Loiseau F, Philouze C, Nasri H. Tetrakis(ethyl-4(4-butyryl)oxyphenyl)porphyrinato zinc complexes with 4,4'-bpyridin: synthesis, characterization, and its catalytic degradation of Calmagite. RSC Adv. 2018 Jun 1;8(36):20143-20156. doi: 10.1039/c8ra01134f. PMID: 35541667; PMCID: PMC9080734. 12: Li S, Yi H, Yuan F, Zhang X, Zhong Y, Huang Y. Oral application of magnesium-L-threonate alleviates radicular pain by inhibiting neuro-inflammation dependent central sensitization of rats. Brain Res. 2024 Sep 15;1839:148910. doi: 10.1016/j.brainres.2024.148910. Epub 2024 Apr 9. PMID: 38604557. 13: Karimi SY, Marofi S, Zare MA. Fabricating pentaazatetraethylene modified sulfonated polyacrylamide for dye adsorption from aqueous media: isotherms and kinetics models. Environ Sci Pollut Res Int. 2024 Apr;31(17):25849-25866. doi: 10.1007/s11356-024-32590-w. Epub 2024 Mar 15. PMID: 38488921. 14: Liedtke RJ, Kroon G. Automated calmagite compleximetric measurement of magnesium in serum, with sequential addition of EDTA to eliminate endogenous interference. Clin Chem. 1984 Nov;30(11):1801-4. PMID: 6435911. 15: Lippi G, Daves M, Mattiuzzi C. Interference of medical contrast media on laboratory testing. Biochem Med (Zagreb). 2014 Feb 15;24(1):80-8. doi: 10.11613/BM.2014.010. PMID: 24627717; PMCID: PMC3936969. 16: Sheriff TS, Cope S, Varsani DS. Kinetics and mechanism of the manganese(II) catalysed Calmagite dye oxidation using in situ generated hydrogen peroxide. Dalton Trans. 2013 Apr 28;42(16):5673-81. doi: 10.1039/c3dt32873b. PMID: 23440053. 17: Ferreira SL, Ferreira JR, Dantas AF, Lemos VA, Araújo NM, Spinola Costa AC. Copper determination in natural water samples by using FAAS after preconcentration onto amberlite XAD-2 loaded with calmagite. Talanta. 2000 Jan 10;50(6):1253-9. doi: 10.1016/s0039-9140(99)00230-1. PMID: 18967821. 18: Abernethy MH, Fowler RT. Micellar improvement of the calmagite compleximetric measurement of magnesium in plasma. Clin Chem. 1982 Mar;28(3):520-2. PMID: 7067096. 19: Ferreira SL, Andrade HM, dos Santos HC. Characterization and determination of the thermodynamic and kinetic properties of the adsorption of the molybdenum(VI)-calmagite complex onto active carbon. J Colloid Interface Sci. 2004 Feb 15;270(2):276-80. doi: 10.1016/j.jcis.2003.07.042. PMID: 14697689. 20: Savory J, Margrey KS, Shipe JR Jr, Savory MG, Margrey MH, Mifflin TE, Wills MR, Boyd JC. Stabilization of the calmagite reagent for automated measurement of magnesium in serum and urine. Clin Chem. 1985 Mar;31(3):487-8. PMID: 3971574.