Synonym
PA21A092; PA-21A092; PA21A092
IUPAC/Chemical Name
N-(4-(4-chloro-2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-yl)-2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)acetamide
InChi Key
AXHVMTZWSKDPRR-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H23ClFN5O/c1-13(2)22-26-18-7-5-6-8-19(18)30(22)12-20(31)27-23-21(14(3)28-29(23)4)16-10-9-15(24)11-17(16)25/h5-11,13H,12H2,1-4H3,(H,27,31)
SMILES Code
O=C(NC1=C(C2=CC=C(Cl)C=C2F)C(C)=NN1C)CN3C4=CC=CC=C4N=C3C(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
439.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tewari SG, Kwan B, Elahi R, Rajaram K, Reifman J, Prigge ST, Vaidya AB,
Wallqvist A. Metabolic adjustments of blood-stage Plasmodium falciparum in
response to sublethal pyrazoleamide exposure. Sci Rep. 2022 Jan 21;12(1):1167.
doi: 10.1038/s41598-022-04985-7. PMID: 35064153; PMCID: PMC8782945.
2: Mohring F, van Schalkwyk DA, Henrici RC, Blasco B, Leroy D, Sutherland CJ,
Moon RW. Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite
Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs.
mBio. 2022 Oct 26;13(5):e0117822. doi: 10.1128/mbio.01178-22. Epub 2022 Oct 3.
PMID: 36190127; PMCID: PMC9600963.
3: Tewari SG, Elahi R, Kwan B, Rajaram K, Bhatnagar S, Reifman J, Prigge ST,
Vaidya AB, Wallqvist A. Metabolic responses in blood-stage malaria parasites
associated with increased and decreased sensitivity to PfATP4 inhibitors. Malar
J. 2023 Feb 14;22(1):56. doi: 10.1186/s12936-023-04481-x. PMID: 36788578; PMCID:
PMC9930341.
