Sulfanegen | CAS#80003-64-1 | biochemical

MedKoo Cat#: 146097 | Name: Sulfanegen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfanegen is a synthetic compound primarily used for its antimicrobial and anti-inflammatory properties. It has been studied for its potential application in treating infections, particularly those caused by resistant bacteria, as well as in managing inflammatory conditions. The mechanism of action of sulfanegen involves the inhibition of bacterial folate synthesis, disrupting their ability to produce essential nucleic acids, leading to bacterial cell death. Its anti-inflammatory effects are believed to arise from the suppression of pro-inflammatory cytokine production, helping reduce tissue inflammation.

Chemical Structure

Sulfanegen

CAS#80003-64-1

Theoretical Analysis

MedKoo Cat#: 146097

Name: Sulfanegen

CAS#: 80003-64-1

Chemical Formula: C6H8O6S2

Exact Mass: 239.9762

Molecular Weight: 240.24

Elemental Analysis: C, 30.00; H, 3.36; O, 39.96; S, 26.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Sulfanegen;

IUPAC/Chemical Name

2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylic acid

InChi Key

GYZMXMSJOZUNEQ-UHFFFAOYSA-N

InChi Code

1S/C6H8O6S2/c7-3(8)5(11)1-13-6(12,2-14-5)4(9)10/h11-12H,1-2H2,(H,7,8)(H,9,10)

SMILES Code

OC(=O)C1(O)CSC(O)(CS1)C(O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 240.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rao SP, Xie W, Christopher Kwon YI, Juckel N, Xie J, Dronamraju VR, Vince R, Lee MK, More SS. Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo. Redox Biol. 2022 Nov;57:102484. doi: 10.1016/j.redox.2022.102484. Epub 2022 Sep 26. PMID: 36183541; PMCID: PMC9530613. 2: Patterson SE, Moeller B, Nagasawa HT, Vince R, Crankshaw DL, Briggs J, Stutelberg MW, Vinnakota CV, Logue BA. Development of sulfanegen for mass cyanide casualties. Ann N Y Acad Sci. 2016 Jun;1374(1):202-9. doi: 10.1111/nyas.13114. Epub 2016 Jun 16. PMID: 27308865; PMCID: PMC4940216. 3: Brenner M, Kim JG, Lee J, Mahon SB, Lemor D, Ahdout R, Boss GR, Blackledge W, Jann L, Nagasawa HT, Patterson SE. Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity. Toxicol Appl Pharmacol. 2010 Nov 1;248(3):269-76. doi: 10.1016/j.taap.2010.08.002. Epub 2010 Aug 10. PMID: 20705081; PMCID: PMC3382974. 4: Belani KG, Singh H, Beebe DS, George P, Patterson SE, Nagasawa HT, Vince R. Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium. Anesth Analg. 2012 May;114(5):956-61. doi: 10.1213/ANE.0b013e31824c4eb5. Epub 2012 Mar 5. PMID: 22392971; PMCID: PMC3334426. 5: Patterson SE, Monteil AR, Cohen JF, Crankshaw DL, Vince R, Nagasawa HT. Cyanide antidotes for mass casualties: water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration. J Med Chem. 2013 Feb 14;56(3):1346-9. doi: 10.1021/jm301633x. Epub 2013 Jan 30. PMID: 23301495; PMCID: PMC3575131. 6: Chan A, Crankshaw DL, Monteil A, Patterson SE, Nagasawa HT, Briggs JE, Kozocas JA, Mahon SB, Brenner M, Pilz RB, Bigby TD, Boss GR. The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning. Clin Toxicol (Phila). 2011 Jun;49(5):366-73. doi: 10.3109/15563650.2011.584879. PMID: 21740135; PMCID: PMC3882312. 7: Hottinger DG, Beebe DS, Kozhimannil T, Prielipp RC, Belani KG. Sodium nitroprusside in 2014: A clinical concepts review. J Anaesthesiol Clin Pharmacol. 2014 Oct;30(4):462-71. doi: 10.4103/0970-9185.142799. PMID: 25425768; PMCID: PMC4234779. 8: Moeller BM, Crankshaw DL, Briggs J, Nagasawa HT, Patterson SE. In-vitro mercaptopyruvate sulfurtransferase species comparison in humans and common laboratory animals. Toxicol Lett. 2017 May 15;274:64-68. doi: 10.1016/j.toxlet.2017.04.005. Epub 2017 Apr 12. PMID: 28412453; PMCID: PMC5505176. 9: Rao SP, Dobariya P, Bellamkonda H, More SS. Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease. Antioxidants (Basel). 2023 Mar 1;12(3):603. doi: 10.3390/antiox12030603. PMID: 36978851; PMCID: PMC10045210. 10: Kim JG, Lee J, Mahon SB, Mukai D, Patterson SE, Boss GR, Tromberg BJ, Brenner M. Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism. J Biomed Opt. 2012 Oct;17(10):105005. doi: 10.1117/1.JBO.17.10.105005. PMID: 23223999; PMCID: PMC3603151. 11: Stutelberg MW, Vinnakota CV, Mitchell BL, Monteil AR, Patterson SE, Logue BA. Determination of 3-mercaptopyruvate in rabbit plasma by high performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 15;949-950:94-8. doi: 10.1016/j.jchromb.2014.01.006. Epub 2014 Jan 18. PMID: 24480329; PMCID: PMC3989840. 12: Petrikovics I, Budai M, Kovacs K, Thompson DE. Past, present and future of cyanide antagonism research: From the early remedies to the current therapies. World J Methodol. 2015 Jun 26;5(2):88-100. doi: 10.5662/wjm.v5.i2.88. PMID: 26140275; PMCID: PMC4482825. 13: Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:181-188. doi: 10.1016/j.jchromb.2015.11.027. Epub 2015 Nov 21. PMID: 26655110.