T15787 | CAS#1252362-53-0 | sAC inhibitor

MedKoo Cat#: 526479 | Name: LRE1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T15787, also known as LRE1, is a novel specific and allosteric inhibitor of soluble adenylyl cyclase (sAC), binding to the bicarbonate activator binding site and inhibiting sAC via a unique allosteric mechanism, preventing sAC-dependent processes in cellular and physiological systems.

Chemical Structure

LRE1

CAS#1252362-53-0

Theoretical Analysis

MedKoo Cat#: 526479

Name: LRE1

CAS#: 1252362-53-0

Chemical Formula: C12H13ClN4S

Exact Mass: 280.0500

Molecular Weight: 280.77

Elemental Analysis: C, 51.33; H, 4.67; Cl, 12.63; N, 19.95; S, 11.42

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
200mg	USD 1,650.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

1252362-53-0

Synonym

LRE1, T15787; T-15787; T 15787;

IUPAC/Chemical Name

6-Chloro-4-N-cyclopropyl-4-N-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine

InChi Key

PDWZXKSZLRVSEH-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H13ClN4S/c13-10-6-11(16-12(14)15-10)17(8-3-4-8)7-9-2-1-5-18-9/h1-2,5-6,8H,3-4,7H2,(H2,14,15,16)

SMILES Code

NC1=NC(Cl)=CC(N(C2CC2)CC3=CC=CS3)=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 280.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C, Zippin JH, van den Heuvel J, Glickman JF, Steegborn C, Levin LR, Buck J. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol. 2016 Oct;12(10):838-44. doi: 10.1038/nchembio.2151. Epub 2016 Aug 22. PubMed PMID: 27547922; PubMed Central PMCID: PMC5030147. 2: Mancini Lombardi I, Palani S, Meitinger F, Darieva Z, Hofmann A, Sharrocks AD, Pereira G. Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner. Curr Biol. 2013 Sep 23;23(18):1736-45. doi: 10.1016/j.cub.2013.07.032. Epub 2013 Aug 15. PubMed PMID: 23954433. 3: Furniss CS, Marsit CJ, Houseman EA, Eddy K, Kelsey KT. Line region hypomethylation is associated with lifestyle and differs by human papillomavirus status in head and neck squamous cell carcinomas. Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):966-71. doi: 10.1158/1055-9965.EPI-07-2775. PubMed PMID: 18398038; PubMed Central PMCID: PMC2633874. 4: Choi SH, Byun HM, Kwan JM, Issa JP, Yang AS. Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition. Br J Haematol. 2007 Sep;138(5):616-23. PubMed PMID: 17686055. 5: Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT. Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):108-14. PubMed PMID: 17220338. 6: Sekiya-Kawasaki M, Abe M, Saka A, Watanabe D, Kono K, Minemura-Asakawa M, Ishihara S, Watanabe T, Ohya Y. Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics. 2002 Oct;162(2):663-76. PubMed PMID: 12399379; PubMed Central PMCID: PMC1462274. 7: Mayordomo I, Sanz P. The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein. Biochem J. 2002 Jul 1;365(Pt 1):51-6. PubMed PMID: 11931638; PubMed Central PMCID: PMC1222645. 8: Versele M, Thevelein JM. Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae. Mol Microbiol. 2001 Sep;41(6):1311-26. PubMed PMID: 11580836. 9: Alonso-Monge R, Real E, Wojda I, Bebelman JP, Mager WH, Siderius M. Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects. Mol Microbiol. 2001 Aug;41(3):717-30. PubMed PMID: 11532139. 10: Bialek-Wyrzykowska U, Bauer BE, Wagner W, Kohlwein SD, Schweyen RJ, Ragnini A. Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance. Mol Microbiol. 2000 Mar;35(6):1295-311. PubMed PMID: 10760132. 11: DeBerardinis RJ, Kazazian HH Jr. Full-length L1 elements have arisen recently in the same 1-kb region of the gorilla and human genomes. J Mol Evol. 1998 Sep;47(3):292-301. PubMed PMID: 9732456. 12: Lai MH, Silverman SJ, Gaughran JP, Kirsch DR. Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Yeast. 1997 Mar 15;13(3):199-213. PubMed PMID: 9090049. 13: Smith MF Jr, Eidlen D, Arend WP, Gutierrez-Hartmann A. LPS-induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements. J Immunol. 1994 Oct 15;153(8):3584-93. PubMed PMID: 7930581. 14: Holmes SE, Dombroski BA, Krebs CM, Boehm CD, Kazazian HH Jr. A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion. Nat Genet. 1994 Jun;7(2):143-8. PubMed PMID: 7920631.