MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 208378 | Name: SAR7334 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SAR7334 hydrochloride is a specific inhibitor of TRPC3/6/7

Chemical Structure

SAR7334 hydrochloride
SAR7334 hydrochloride
CAS#1333207-63-8

Theoretical Analysis

MedKoo Cat#: 208378

Name: SAR7334 hydrochloride

CAS#: 1333207-63-8

Chemical Formula: C21H24Cl3N3O

Exact Mass: 439.0985

Molecular Weight: 440.79

Elemental Analysis: C, 57.22; H, 5.49; Cl, 24.13; N, 9.53; O, 3.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SAR7334-hydrochloride, SAR-7334 hydrochloride
IUPAC/Chemical Name
4-[[(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile;dihydrochloride
InChi Key
LFMYIKNZNTZSJX-IQJQELQDSA-N
InChi Code
InChI=1S/C21H22ClN3O.2ClH/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25;;/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2;2*1H/t16-,19-,21-;;/m1../s1
SMILES Code
N#CC1=CC=C(O[C@H]2[C@H](N3C[C@H](N)CCC3)CC4=C2C=CC=C4)C(Cl)=C1.[H]Cl.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shen B, Mei M, Ai S, Liao X, Li N, Xiang S, Wen C, Tao Y, Dai H. TRPC6 inhibits renal tubular epithelial cell pyroptosis through regulating zinc influx and alleviates renal ischemia-reperfusion injury. FASEB J. 2022 Oct;36(10):e22527. doi: 10.1096/fj.202200109RR. PMID: 36036542. 2: Feng Y, Li M, Wang Y, Yang M, Shi G, Yin D, Xuan Z, Xu F. Activation of TRPC6 by AngⅡ Induces Podocyte Injury and Participates in Proteinuria of Nephrotic Syndrome. Front Pharmacol. 2022 Aug 3;13:915153. doi: 10.3389/fphar.2022.915153. PMID: 35991898; PMCID: PMC9382118. 3: Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron. 2022 Mar 16;110(6):1023-1035.e5. doi: 10.1016/j.neuron.2021.12.023. Epub 2022 Jan 19. PMID: 35051376. 4: Baradaran-Heravi A, Bauer CC, Pickles IB, Hosseini-Farahabadi S, Balgi AD, Choi K, Linley DM, Beech DJ, Roberge M, Bon RS. Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903. J Biol Chem. 2022 Feb;298(2):101546. doi: 10.1016/j.jbc.2021.101546. Epub 2022 Jan 6. PMID: 34999117; PMCID: PMC8808171. 5: Gyarmati G, Toma I, Izuhara A, Burford JL, Shroff UN, Papadouri S, Deepak S, Peti-Peterdi J. The role of TRPC6 calcium channels and P2 purinergic receptors in podocyte mechanical and metabolic sensing. Physiol Int. 2021 Dec 16:2021.00205. doi: 10.1556/2060.2021.00205. Epub ahead of print. PMID: 34978536; PMCID: PMC9200898. 6: Fang X, Dong S, Wu Y, He Y, Lu M, Shi D, Feng N, Yin S, Jiang Y, Zhang A, Ding Y, Zhang Q, Tang J, Zhang W, He X. Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats. BMC Complement Med Ther. 2021 Jun 22;21(1):173. doi: 10.1186/s12906-021-03345-8. PMID: 34154575; PMCID: PMC8216761. 7: Wierer M, Werner J, Wobst J, Kastrati A, Cepele G, Aherrahrou R, Sager HB, Erdmann J, Dichgans M, Flockerzi V, Civelek M, Dietrich A, Mann M, Schunkert H, Kessler T. A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy. Eur Heart J. 2021 May 7;42(18):1773-1785. doi: 10.1093/eurheartj/ehab140. PMID: 33829256; PMCID: PMC8104955. 8: Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Nov 25;10(4):2045894020956592. doi: 10.1177/2045894020956592. PMID: 33282184; PMCID: PMC7691930. 9: Wang Y, Liu L, Tao H, Wen L, Qin S. TRPC6 participates in the development of blood pressure variability increase in sino-aortic denervated rats. Heart Vessels. 2020 Dec;35(12):1755-1765. doi: 10.1007/s00380-020-01682-1. Epub 2020 Aug 25. PMID: 32844288. 10: Uryash A, Flores V, Adams JA, Allen PD, Lopez JR. Memory and Learning Deficits Are Associated With Ca2+ Dyshomeostasis in Normal Aging. Front Aging Neurosci. 2020 Jul 16;12:224. doi: 10.3389/fnagi.2020.00224. PMID: 32765253; PMCID: PMC7378956.