Synonym
ABT-898; ABT 898; ABT898
IUPAC/Chemical Name
(7S,10R,13S)-10-((S)-sec-butyl)-16-(((2S,3S)-1-(((S)-1-((S)-2-(ethylcarbamoyl)pyrrolidin-1-yl)-5-guanidino-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-13-(hydroxymethyl)-7-isopropyl-2,5,8,11,14-pentaoxo-3,6,12,15-tetraazanonadecan-19-oic acid
InChi Key
RROBICMYRIYKGJ-RQQWOQHCSA-N
InChi Code
InChI=1S/C43H75N11O12/c1-9-24(6)27(20-32(57)35(23(4)5)52-33(58)21-48-26(8)56)37(61)51-30(22-55)39(63)49-28(16-17-34(59)60)38(62)53-36(25(7)10-2)41(65)50-29(14-12-18-47-43(44)45)42(66)54-19-13-15-31(54)40(64)46-11-3/h23-25,27-31,35-36,55H,9-22H2,1-8H3,(H,46,64)(H,48,56)(H,49,63)(H,50,65)(H,51,61)(H,52,58)(H,53,62)(H,59,60)(H4,44,45,47)/t24-,25-,27+,28?,29-,30-,31-,35-,36-/m0/s1
SMILES Code
CC(NCC(N[C@@H](C(C)C)C(C[C@H]([C@@H](C)CC)C(N[C@@H](CO)C(NC(CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N1[C@H](C(NCC)=O)CCC1)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
938.14
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Campbell N, Greenaway J, Henkin J, Petrik J. ABT-898 induces tumor regression
and prolongs survival in a mouse model of epithelial ovarian cancer. Mol Cancer
Ther. 2011 Oct;10(10):1876-85. doi: 10.1158/1535-7163.MCT-11-0402. Epub 2011 Aug
15. PMID: 21844212.
2: Gutierrez LS, Ling J, Nye D, Papathomas K, Dickinson C. Thrombospondin
peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model. World
J Gastroenterol. 2015 May 28;21(20):6157-66. doi: 10.3748/wjg.v21.i20.6157.
PMID: 26034351; PMCID: PMC4445093.
3: Edwards AK, Olariu I, Nakamura DS, Ahn SH, Tayade C. Chronic effects of an
anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on female mouse
reproductive outcomes. Reprod Biol Endocrinol. 2016 Sep 7;14(1):56. doi:
10.1186/s12958-016-0192-7. PMID: 27604347; PMCID: PMC5015213.
4: Nakamura DS, Edwards AK, Virani S, Thomas R, Tayade C. Thrombospondin-1
mimetic peptide ABT-898 affects neovascularization and survival of human
endometriotic lesions in a mouse model. Am J Pathol. 2012 Aug;181(2):570-82.
doi: 10.1016/j.ajpath.2012.05.010. Epub 2012 Jun 19. PMID: 22727957.
5: Recouvreux MV, Camilletti MA, Rifkin DB, Becu-Villalobos D, Díaz-Torga G.
Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth
and recover active pituitary transforming growth factor-β1 (TGF-β1).
Endocrinology. 2012 Aug;153(8):3861-71. doi: 10.1210/en.2012-1007. Epub 2012 Jun
14. PMID: 22700773; PMCID: PMC3404347.
6: Sahora AI, Rusk AW, Henkin J, McKeegan EM, Shi Y, Khanna C. Prospective study
of thrombospondin-1 mimetic peptides, ABT-510 and ABT-898, in dogs with soft
tissue sarcoma. J Vet Intern Med. 2012 Sep-Oct;26(5):1169-76. doi:
10.1111/j.1939-1676.2012.00966.x. Epub 2012 Jul 21. PMID: 22816494.
7: Garside SA, Henkin J, Morris KD, Norvell SM, Thomas FH, Fraser HM. A
thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes
follicular atresia in pre- and early-antral follicles in vivo. Endocrinology.
2010 Dec;151(12):5905-15. doi: 10.1210/en.2010-0283. Epub 2010 Sep 29. PMID:
20881256.
