JKC363 (acetate) | MC4R antagonist

MedKoo Cat#: 128662 | Name: JKC363 (acetate)

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JKC363 is a cyclic peptide antagonist of melanocortin receptor 4 (MC4R) (IC50 = 0.5 nM).

Chemical Structure

JKC363 (acetate)

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128662

Name: JKC363 (acetate)

CAS#: N/A

Chemical Formula: C71H95N19O18S2

Exact Mass: 0.0000

Molecular Weight: 1566.78

Elemental Analysis: C, 54.43; H, 6.11; N, 16.99; O, 18.38; S, 4.09

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 750.00	2 Weeks
10mg	USD 1,050.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

JKC363 (acetate); JKC363; JKC-363; JKC 363

IUPAC/Chemical Name

(S)-3-((S)-2-((S)-1-(((4R,10S,13S,16R,19S,22S)-19-((1H-imidazol-5-yl)methyl)-10-((1H-indol-3-yl)methyl)-22-(2-carboxyethyl)-13-(3-guanidinopropyl)-16-(naphthalen-2-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacosane-4-carbonyl)-L-prolyl)pyrrolidine-2-carboxamido)-6-aminohexanamido)-4-amino-4-oxobutanoic acid--acetic acid (1/1)

InChi Key

IJVLUTUXDRKUQF-FVOJPQBCSA-N

InChi Code

InChI=1S/C69H91N19O16S2.C2H4O2/c70-23-6-5-14-45(61(97)83-48(59(71)95)32-58(93)94)82-66(102)53-16-8-25-87(53)68(104)54-17-9-26-88(54)67(103)52-36-106-105-27-22-55(89)79-47(20-21-57(91)92)63(99)86-51(31-42-34-74-37-78-42)65(101)84-49(29-38-18-19-39-10-1-2-11-40(39)28-38)64(100)81-46(15-7-24-75-69(72)73)62(98)85-50(60(96)77-35-56(90)80-52)30-41-33-76-44-13-4-3-12-43(41)44;1-2(3)4/h1-4,10-13,18-19,28,33-34,37,45-54,76H,5-9,14-17,20-27,29-32,35-36,70H2,(H2,71,95)(H,74,78)(H,77,96)(H,79,89)(H,80,90)(H,81,100)(H,82,102)(H,83,97)(H,84,101)(H,85,98)(H,86,99)(H,91,92)(H,93,94)(H4,72,73,75);1H3,(H,3,4)/t45-,46-,47-,48-,49+,50-,51-,52-,53-,54-;/m0./s1

SMILES Code

O=C([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC(CCSSC[C@H](NC(CNC1=O)=O)C(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC4=CN=CN4)=O)CC5=CC6=C(C=CC=C6)C=C5)=O)CCCNC(N)=N)N[C@H]1CC7=CNC8=CC=CC=C78.CC(O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,566.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Kim, M.S., Small, C.J., Russell, S.H., et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: Evidence for the differential roles of melanocortin 3 and 4 receptors. J. Neuroendocrinol. 14(4), 276-282 (2002). 2. Carniglia, L., Turati, J., Saba, J., et al. Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells. Neuropharmacology 257, 110058 (2024). 3. Bellasio, S., Nicolussi, E., Bertorelli, R., et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur. J. Pharmacol. 482(1-3), 127-132 (2003).