BMS-986308 is a small-molecule inhibitor of the Renal Outer Medullary Potassium (ROMK) channel, also known as Kir1.1 or KCNJ1, which plays a key role in potassium recycling in the thick ascending limb of the nephron and in potassium secretion in the collecting duct. In preclinical studies, BMS-986308 exhibited potent inhibition of ROMK with an IC₅₀ in the low nanomolar range (~20–40 nM in human ROMK-expressing cell lines), leading to increased urinary sodium and decreased potassium excretion. This pharmacodynamic profile supports its potential as a novel antihypertensive agent, particularly in salt-sensitive hypertension or conditions like hyperaldosteronism.
MedKoo Cat#: 127101
Name: BMS-986308
CAS#: 2254333-97-4
Chemical Formula: C24H25N7O2
Exact Mass: 443.2070
Molecular Weight: 443.51
Elemental Analysis: C, 65.00; H, 5.68; N, 22.11; O, 7.21
The following data is based on the product molecular weight 443.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
