MedKoo Cat#: 128606 | Name: NLRP3/AIM2-IN-3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis.

Chemical Structure

NLRP3/AIM2-IN-3
CAS#1787787-60-3

Theoretical Analysis

MedKoo Cat#: 128606

Name: NLRP3/AIM2-IN-3

CAS#: 1787787-60-3

Chemical Formula: C16H14N2O2

Exact Mass: 266.1055

Molecular Weight: 266.30

Elemental Analysis: C, 72.17; H, 5.30; N, 10.52; O, 12.02

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
NLRP3/AIM2-IN-3; NLRP3-AIM2-IN-3; NLRP3/AIM2 IN 3;
IUPAC/Chemical Name
N-(3-hydroxyphenyl)-2-(1H-indol-6-yl)acetamide
InChi Key
UOBOMCZZCHPHBU-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14N2O2/c19-14-3-1-2-13(10-14)18-16(20)9-11-4-5-12-6-7-17-15(12)8-11/h1-8,10,17,19H,9H2,(H,18,20)
SMILES Code
O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 266.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Jiao Y, Nan J, Mu B, Zhang Y, Zhou N, Yang S, Zhang S, Lin W, Wang F, Xia A, Cao Z, Chen P, Pan Z, Lin G, Pan S, Bin H, Li L, Yang S. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Mar 15;232:114194. doi: 10.1016/j.ejmech.2022.114194. Epub 2022 Feb 11. PMID: 35183871.