Synonym
OPB-3206; OPB3206; OPB 3206;
IUPAC/Chemical Name
(R)-N4-hydroxy-2-isobutyl-N1-((S)-1-methoxy-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)succinamide
InChi Key
OIVAPLYJZKBFMV-KGLIPLIRSA-N
InChi Code
1S/C18H25N3O5/c1-11(2)8-13(10-16(22)20-25)17(23)19-14-9-12-6-4-5-7-15(12)21(26-3)18(14)24/h4-7,11,13-14,25H,8-10H2,1-3H3,(H,19,23)(H,20,22)/t13-,14+/m1/s1
SMILES Code
CON1C(=O)[C@H](CC2=CC=CC=C12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
363.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wojtowicz-Praga S. Clinical potential of matrix metalloprotease inhibitors. Drugs R D. 1999 Feb;1(2):117-29. doi: 10.2165/00126839-199901020-00001. PMID: 10566004.
2: Shono T, Motoyama M, Tatsumi K, Ulbrich N, Iwamoto Y, Kuwano M, Ono M. A new synthetic matrix metalloproteinase inhibitor modulates both angiogenesis and urokinase type plasminogen activator activity. Angiogenesis. 1998;2(4):319-29. doi: 10.1023/a:1009207820233. PMID: 14517452.
3: Iki K, Tsutsumi M, Kido A, Sakitani H, Takahama M, Yoshimoto M, Motoyama M, Tatsumi K, Tsunoda T, Konishi Y. Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. Carcinogenesis. 1999 Jul;20(7):1323-9. doi: 10.1093/carcin/20.7.1323. PMID: 10383907.
4: Kido A, Tsutsumi M, Iki K, Motoyama M, Takahama M, Tsujiuchi T, Morishita T, Tatsumi K, Tamai S, Konishi Y. Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor. Jpn J Cancer Res. 1999 Mar;90(3):333-41. doi: 10.1111/j.1349-7006.1999.tb00752.x. PMID: 10359049; PMCID: PMC5926067.
