MedKoo Cat#: 563907 | Name: GSK3277329

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK3277329 is an agonist of toll-like receptor 2 (TLR2). GSK3277329 stimulates the release of G-CSF in activated THP-1 cells; peripheral blood mononuclear cells; and human umbilical vein endothelial cells.

Chemical Structure

GSK3277329
GSK3277329
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 563907

Name: GSK3277329

CAS#: NONE

Chemical Formula: C36H70N6O8S

Exact Mass: 746.4976

Molecular Weight: 747.05

Elemental Analysis: C, 57.88; H, 9.45; N, 11.25; O, 17.13; S, 4.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GSK3277329; GSK-3277329; GSK 3277329; Pam-Cys-Ser-D-Lys-D-Lys; PamCysSerDLysDLys
IUPAC/Chemical Name
S-(2-(Palmitoyloxy)ethyl)-L-cysteinyl-L-seryl-D-lysyl-D-lysine; (2R,5R,8S,11R)-11-amino-2,5-bis(4-aminobutyl)-8-(hydroxymethyl)-4,7,10,17-tetraoxo-16-oxa-13-thia-3,6,9-triazadotriacontan-1-oic acid
InChi Key
DHWLJAQECJGSON-KQFVITFDSA-N
InChi Code
InChI=1S/C36H70N6O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-21-32(44)50-24-25-51-27-28(39)33(45)42-31(26-43)35(47)40-29(19-15-17-22-37)34(46)41-30(36(48)49)20-16-18-23-38/h28-31,43H,2-27,37-39H2,1H3,(H,40,47)(H,41,46)(H,42,45)(H,48,49)/t28-,29+,30+,31-/m0/s1
SMILES Code
NCCCC[C@H](C(O)=O)NC([C@@H](CCCCN)NC([C@H](CO)NC([C@H](CSCCOC(CCCCCCCCCCCCCCC)=O)N)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 747.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Laping NJ, DeMartino MP, Cottom JE, Axten JM, Emery JG, Guss JH, Burman M, Foley JJ, Cheung M, Oliff A, Kumar S. TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis. Blood Adv. 2017 Dec 8;1(26):2553-2562. doi: 10.1182/bloodadvances.2017010611. eCollection 2017 Dec 12. PubMed PMID: 29296907; PubMed Central PMCID: PMC5728636.