MedKoo Cat#: 328210 | Name: Tosufloxacin tosylate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tosufloxacin, also known as T-3262, is a fluoroquinolone antibiotic used to treat susceptible infections. It has a controversial safety profile in relation to other fluoroquinolones. It is associated with severe thrombocytopenia and nephritis, and hepatotoxicity. It is sold in Japan under the brand name Ozex.

Chemical Structure

Tosufloxacin tosylate
Tosufloxacin tosylate
CAS#115964-29-9 (tosylate)

Theoretical Analysis

MedKoo Cat#: 328210

Name: Tosufloxacin tosylate

CAS#: 115964-29-9 (tosylate)

Chemical Formula: C26H23F3N4O6S

Exact Mass: 404.1096

Molecular Weight: 576.55

Elemental Analysis: C, 54.16; H, 4.02; F, 9.89; N, 9.72; O, 16.65; S, 5.56

Price and Availability

Size Price Availability Quantity
100mg USD 150.00 Ready to ship
200mg USD 250.00 Ready to ship
500mg USD 550.00 Ready to ship
1g USD 950.00 2 Weeks
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Synonym
Tosufloxacin; T-3262; T3262; T 3262; Tosufloxacin tosylate
IUPAC/Chemical Name
7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid tosylate
InChi Key
CSSQVOKOWWIUCX-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H15F3N4O3.C7H8O3S/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25;1-6-2-4-7(5-3-6)11(8,9)10/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29);2-5H,1H3,(H,8,9,10)
SMILES Code
O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4CC(N)CC4)=C(F)C=C3C1=O)O.OS(=O)(C5=CC=C(C)C=C5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 576.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takahashi N, Fujita Y, Takahashi N, Nakamura A, Harada T. Effect of xanthan gum-based food thickeners on the dissolution profile of fluoroquinolones oral formulations. J Pharm Health Care Sci. 2020 Nov 30;6(1):25. doi: 10.1186/s40780-020-00181-9. PMID: 33292643; PMCID: PMC7708189. 2: Jin B, Guo K, Zhang T, Li T, Ma C. Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS. J Anal Methods Chem. 2019 Oct 7;2019:4059765. doi: 10.1155/2019/4059765. PMID: 31687249; PMCID: PMC6800909. 3: Deng FY, Huang CX, Liu Y. [Mn2+-cTMAB-sensitized fluorescent microscopic determination of tosufloxacin tosylate based on a self-ordered ring]. Guang Pu Xue Yu Guang Pu Fen Xi. 2014 Feb;34(2):445-9. Chinese. PMID: 24822418. 4: Aubert G, Pozzetto B, Dorche G. Activité antibactérienne in vitro de la témafloxacine et de la tosufloxacine sur les streptocoques [In vitro bactericidal effect of temafloxacin and tosufloxacin against streptococci]. Pathol Biol (Paris). 1991 Dec;39(10):1002-5. French. PMID: 1666667. 5: Chu DT, Lico IM, Swanson RN, Marsh KC, Plattner JJ, Pernet AG. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs Exp Clin Res. 1990;16(9):435-43. PMID: 2100244. 6: Barry AL, Jones RN. In-vitro activities of temafloxacin, tosufloxacin (A-61827) and five other fluoroquinolone agents. J Antimicrob Chemother. 1989 Apr;23(4):527-35. doi: 10.1093/jac/23.4.527. PMID: 2745259.