RWJ-68022 is a selective inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which plays a critical role in converting inactive cortisone into active cortisol in tissues. By inhibiting 11β-HSD1, RWJ-68022 helps reduce the local production of cortisol, which can have beneficial effects on conditions associated with excess cortisol, such as metabolic syndrome, obesity, and diabetes. Its mechanism involves modulating cortisol levels, thereby improving insulin sensitivity and reducing inflammation. RWJ-68022 is being explored as a potential therapeutic for managing metabolic diseases, particularly those linked to cortisol dysregulation.
MedKoo Cat#: 146004
Name: RWJ-68022
CAS#: 223442-22-6
Chemical Formula: C34H37Cl3N4O4
Exact Mass: 670.1900
Molecular Weight: 672.04
Elemental Analysis: C, 60.77; H, 5.55; Cl, 15.82; N, 8.34; O, 9.52
The following data is based on the product molecular weight 672.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |