MedKoo Cat#: 146004 | Name: RWJ-68022

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RWJ-68022 is a selective inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which plays a critical role in converting inactive cortisone into active cortisol in tissues. By inhibiting 11β-HSD1, RWJ-68022 helps reduce the local production of cortisol, which can have beneficial effects on conditions associated with excess cortisol, such as metabolic syndrome, obesity, and diabetes. Its mechanism involves modulating cortisol levels, thereby improving insulin sensitivity and reducing inflammation. RWJ-68022 is being explored as a potential therapeutic for managing metabolic diseases, particularly those linked to cortisol dysregulation.

Chemical Structure

RWJ-68022
RWJ-68022
CAS#223442-22-6

Theoretical Analysis

MedKoo Cat#: 146004

Name: RWJ-68022

CAS#: 223442-22-6

Chemical Formula: C34H37Cl3N4O4

Exact Mass: 670.1900

Molecular Weight: 672.04

Elemental Analysis: C, 60.77; H, 5.55; Cl, 15.82; N, 8.34; O, 9.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
RWJ-68022; RWJ68022; RWJ 68022;
IUPAC/Chemical Name
(S)-N-(1-benzyl-3-((1-(3-(2-morpholinoethoxy)phenyl)-3-phenylureido)methyl)cyclopent-2-en-1-yl)-2,2,2-trichloroacetamide
InChi Key
DPBURRXPRULCQN-XIFFEERXSA-N
InChi Code
1S/C34H37Cl3N4O4/c35-34(36,37)31(42)39-33(23-26-8-3-1-4-9-26)15-14-27(24-33)25-41(32(43)38-28-10-5-2-6-11-28)29-12-7-13-30(22-29)45-21-18-40-16-19-44-20-17-40/h1-13,22,24H,14-21,23,25H2,(H,38,43)(H,39,42)/t33-/m0/s1
SMILES Code
ClC(Cl)(Cl)C(=O)N[C@]2(CC1=CC=CC=C1)CCC(CN(C(=O)NC3=CC=CC=C3)C4=CC=CC(OCCN5CCOCC5)=C4)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 672.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL